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Now LegalZoom is making it easier for you to say so long the summer by Saving you 10% off the things that you need to accomplish for. All you entrepreneurs that haven't set up an LLC a DBA or an escort for your business. Now's the Time to save money. And if you have been meaning to wrap up your last will or living trust but can't seem to find the time take a moment do the right thing for your family. Are you confused or have questions? Well, don't let that slow you down LegalZoom is not a law firm, but their network of independent attorneys and tax professionals can give you the advice that you need to make the right decisions save 10% for a limited time on the things that you have been meaning to do with LegalZoom. Just go to legalzoom.com right now and use the code Rogan at check out Legal Zoom where life meets legal my guest today is a brilliant scientist. He's been on the past and I fucking love the episode and we have a new one that we just did and I think it's even better.
He's amazing and he has a new book out called lifespan why we age and why we don't have to this is one of the most informative podcasts you were ever going to run across when it comes to aging and some really fascinating new information that's available for your ears and eyes. Please give it up for David Sinclair.
The Joe Rogan Experience trained by day Joe Rogan podcast by night David Sinclair lifespan why we age and why we don't have to I'm so happy. There are people like you out there because I don't want to age I'm aging clearly but uh not interested in it. I don't like it. Yeah. Well, I don't know anybody who does Joe Rogan. Thanks having me back on. Thanks for coming back. The first one was a Smash Hit Man people loved it. All my friends were very excited. But I had a question for you right off the bat regarding metformin there was actually an article. I'm sure you saw it recently like within the last couple of days that was going around through all the mainstream papers. It was talking about how the use of Metformin DHEA and was there something else as well that was taking two years human growth hormone taking two years to biological years off of people's lives in terms of their
Their age with your natural 8 with your actual I'm 52 would make me 50, right even 49.5 coating of study. That's how's that for? Yeah that was act to the that was a good study. You know, it's only nine people. So we have to repeat this with a studs. What did you get like nine super athletes or did you get like schmoes that don't exercise as far as I know. These were just regular schmoes schmoes. Yeah, which is good news smells like me. Yes. Good news. Yeah. Well, I mean that's what you want. You don't want like some people just respond better. They have super bodies. You know, look what great thing about that study is first of all, I was with the first the main author on that paper while I came out. I was over in Israel as part of my journey up the Great Rift of Africa ended up in Israel. Anyway, the guy there Steve Horvath is his name he and I and a couple of other guys are trying to figure out not just why we age why we don't have to but is aging truly reversible.
And that's what this study suggests is that it's not just about slowing down aging but one day we could be 80 but biologically 30 now when we're talking about the biological age. How is that measured this is measured by the length of the telomeres is measured by physical performance is it measured by a combination of these factors? It's none of that not something brand-new. Most people don't know about it. So it's called the Horvath clock and what Horvath and others have discovered is that if you read the DNA and you don't just look at the letters actg if you look at what's on the letter c sizings called there are chemical modifications and those chemicals change as we get older in very linear and predictable ways. If you use a computer AI you can say if I took your blood sample right now, I could read your DNA look at those chemical groups on the Seas and I could say you are okay 52, you might be 46
To that clock and also I could predict when you're going to die. Whoa. Scary thought right? Yeah, like a fortune teller. Yeah, but the good news is well now that we know what's not just measuring aging. We actually think that clock is part of the aging process. We're learning how to reverse it to. Hmm. Now is this just one modality this this combination of growth hormone. Is this one way of going about it. Are there other ways of going about it growth hormone DHEA metformin. Is there anything else? Well, that's the first that's ever been trying to just those three things us, but I'm sure there's going to be many more discovered. We've only had this whole Dethklok over the last few years in humans being used widely, but I think as we use this clock we're going to figure out that whole bunch of stuff that we do and things that we can do and combine will not just slow aging but reverse it and not just by two and a half years eventually and some of the technology that I talk about in my book we think could turn
Clock back by a decade or more. Whoa. Now what things are you talking about? That could possibly turn it back a decade or more. Well, so the and who do I have to blow? Sorry? Yeah, you can blow me. But yeah, you may have to do it a few times but the amazing thing about where we are now today with aging and we're right on The Cutting Edge, so it's great to be able to share this with your listeners is this clock it's changed on the DNA. Right what I'm saying in my Theory of Aging is that it's not the DNA that we lose. That's the old Theory, you know, the old idea that antioxidants hurt the deers just throw that out for a while maybe forever. What I think is going on is that the DNA is getting modified and the cell can't read the DNA the way it used to. Okay, that's really important. And so the clock is not just a clock. It's not a clock on the wall. It's
So if you move the hands of the clock time changes, that's what I think is going on. Can we pause right here for a moment and explain what you were saying about antioxidants? Well antioxidants have been the biggest disappointment in the Aging field doesn't stop 40 million people every day buying drinks with antioxidants in them. But antioxidants have with very few exceptions failed to extend the lifespan of any organism, but you are a proponent of Resveratrol at least you used to be. Are you still I still take it and we still study at my lab. But what's you brought this up is really important Resveratrol was originally thought to be an antioxidant and it is a mild antioxidant but the way it really works we know this is a fact from my lab is that it's stimulating the body's defenses against aging and disease because it's binding to these enzymes that we work on called sirtuins, and these are the Defenders of the body and you were saying the if I remember correctly you take Resveratrol you take
Powdered form actually bought exactly what you take and you mix it with yogurt in the morning. Is that is how you do it? Yep. What's the dose that you take? Well probably comes out to about a gram gram. Yeah. Okay, so if someone's taking capsules
What depends if probably capsules at 250 milligrams, that'd be okay. So in the morning, yeah, you know, I'm still alive. It's so that's it's working. Look good. Oh, thank you. Do you is it important to take it with fats? Is that why you take it with yogurt? Yeah. Yeah, either high protein, which is a Greek yogurt surfaces or fact but water it's like break dust it won't dissolve and okay absorbed but a glass of whole milk maybe would be okay. That's great. But it has to have something to bind to is that the deal for sure. Yeah in our studies in humans and in mice if we didn't give them high fat food it barely got in those five fold lipless. Now this study of Metformin DHEA and human growth hormone does not include an MN.
Right, so but nmn is also effective. Well, let's delve in a little bit, please if you read the paper and I have turns out one of the effects of this treatment was the reduction in the levels of a protein called cd38 cd38 resides on immune cells and it goes up as we get older and what they found one of the biggest effects of the treatment was the levels of this cd38 protein went down. So what is the cd38? This is the main enzyme in our bodies that degrades NAD NAD is required for the sore to and Defenders to work. So one possibility is that and I'm sure it's complicated but one way this could be working is by allowing your body to make an ADD and store it rather than degrading it as we get older.
Interesting. So would supplementing with NM n which is a form of NAD. Correct a precursor. Yeah precursor. Would that enhance the effects do you believe like if they try to do a new study it could could it could only teach each of these patients cost $10,000 for the treatment. So it's not easy to do these studies $10,000 for the entirety of the treatment and the treatment lasts how long I've don't remember how long they treated the patients were but I do know that it wasn't cheap. That's why they only did nine because I've first I said to my friend Steve Horvath nine patients you kidding me. Why didn't you do 50 and I went well we didn't have the money. That's the wrong. Anyway, my point really is that we need to test a lot of different combinations include animation include a there's one called rapamycin which is a little bit more risky and toxic but there are better molecules in development. The question is what is the best combination and do
Use it with exercise and fasting or is it bad to combine them all together? We don't know yet. That's a good question to that. I wanted to ask you because one of the things that came out of the podcast was input from some other people that I know that are nutrition experts and performance experts that were skeptical about metformin and they were saying that metformin although it may have an anti-aging effect. It actually decreases physical performance and athletes. Well that there was a study that shows that and was virtual to actually real can prevent the great gains from hot exercise. So here's the solution of that I think is worth trying a solution and that is a theme that I have in my book and in my my research and that is we don't want to be doing everything everyday necessarily we want to pulse it. We want to shock the body and let it recover. We know that you can't just exercise. I mean some people have been on this show run a hundred miles every every weekend, but generally you want to hit it hard and let it recover hit it hard.
Cut so what I am planning to do and actually started doing is on days that I'm exercising in recovering. I don't take metformin and then when I'm just sitting around on a plane I do and that way I think that my body can have the best of both worlds. So when you are not exercising and you take it you feel like it doesn't have a hit when you are exercising and not taking it so it's somehow or another whatever performance hit. It has its temporary. Yeah, right. So well, this is all just theoretical it is we're right on The Cutting Edge of human knowledge. We don't actually know what the best thing is, but my best guess is that we want to allow the body to recover. So I don't take Metformin on those days rather than taking metformin every day like a diabetic would mmm now what are what is the what's that hit like what is happening? What's the mechanism behind the performance hit from taking metformin?
We don't know but I can tell you the best explanation that I can give you so metformin is a derivative of plant molecule the French lilac so it's not crazy molecule. It's pretty natural. But what it does is many things in the body scientists will quite annoyingly argue about it for they have for the live past 40 years. So there's no correct answer but what I think is going on is that metformin is interfering with the mitochondria mitochondria in the cell mitochondria that we call the battery packs. They basically making chemical energy without that chemical energy. We'd be dead in about 20 seconds. So we need that for life. So metformin interrupts that energy production in the mitochondria, but you need the mitochondria to amplify after you've exercised. So there are antagonizing each other. So why does metformin work by inhibiting the mitochondria the body gets a signal that it doesn't have enough chemical energy. It's not making enough. So it expands the number of mitochondria. These are ancient
Remnants of bacteria that entered ourselves and we have less if we sit around and like we are now and we have more if you exercise and Metformin by telling the body a shit, we're running out of energy the body responds to makes more mitochondria just like exercise does but I think if you're taking metformin and exercising that inhibition is preventing the benefit somehow of what you get with exercise, perhaps preventing your house. So like what did the study or what studies have been done? And what did they reveal? I don't remember the precise details of the study. It was it was giving metformin every day to people who were in a controlled exercise. I think was treadmill a few times a week, but then what they measured was the mitochondrial benefit now that and I think they measured a bit of strength so confusing that there's a modal mitochondrial benefit but a performance hit well, no, they actually metformin prevented the mitochondria from amplifying up. Oh, all right, so then it must
Be interfering with the signal that you get from exercise. Whatever. That is. We don't know exactly what that is.
So you really have to be some sort of a guinea pig try to fuck with this stuff to go back and forth from taking it and exercising not taking it. Yeah, I'm sighs. I'm one of those guinea pigs. Yeah. And what do you mean? No disrespect when how hard are you working out not enough, you know if I can say it's been three hours a week in the gym. That's not bad. It's all in one day that's maintenance or one day. Yeah, really one day three hours. Yeah, that's ridiculous. Are you doing it that way because I'm a smart but you're so smart that drives me crazy when smart people do dumb shit. Like I had Peter hotez on the podcast. He's a brilliant man and from the University of Texas. He's a researcher in tropical diseases and he's obsessed with diseases and the importance of vaccinations all these different things that he's talking about how he is died is terrible junk food is constantly Jack-in-the-Box and Shadow. I'm like what the fuck man? You're so smart and you're a guy who works on diseases. What's the number one cause of
Diseases. Yeah, I don't get that some of my colleagues at the worst food and they study longevity crazy. It's crazy. It's like they can't help their impulses. It's like there's so many people like that that are obsessed with various aspects of health and performance, but they just they just can't get it together. Well, I would work out more if I had time. I'm usually working till midnight and after that I'm not really can you go to the gym. You do have an excuse you have a crazy work schedule. You do have an excuse. Yeah. Well, I'm on planes Fair bit. So I tried exercise on the planes pretty hard. Do you really want bathroom you guys trash, you know squat. So now he thinks you're crazy. Yeah. I've Got a Pea Lottery doing blowing there something you haven't done this for a while people think you're in there doing math. Yeah doing something in there once
Yeah, um, so what do you do when you work out I lift weights for an hour, then do a fair bit of stretching and then and then I actually do some hot and cold treatment. Okay? Yeah, you remember we did the cryotherapy last time. Yes. Yeah. That was fantastic. Yeah, I want to do it again today if you time I'll do antastic Man 2. Yeah still planning on doing it today. I did hot yoga or earlier. So I like to do hot yoga in the morning and then cryo after podcast. So I like to mix it up. Right? Let's do it. All right. I don't have a cryo handy at my place. But I do the sauna and then called up and you should get a cry out set up. They're not that expensive. You get one. What about these infrared boxes there? Any good 04 saunas? I do not know but some people swear by them Laird Hamilton who were talking about by the way Huggers are coughing. It's fantastic. Swear my able to pump up superfood coffee. Well, we'll get you more. Well, oh Jeff is going off to pick up our Pablo Escobar mug.
Picture I'm obsessed with mug shots for some strange reason always and selecting new mug shot pictures got a giant Pablo Escobar. It's very nice. The Laird Hamilton stuff is that's got turmeric. It's got coconut milk. It's organic coffee. I'm so addicted to it. I drink that stuff like water. Yeah, I'm gonna have to get myself. So yeah, it's delicious. He's taught me good. Just you don't need a machine either can mix it yourself. He has all the stuff you just poured into coughing. Yeah. I mean, he's a hero of mine for a stud was he's 50 something that's a thousand years old guy runs mountains fucking surf things tall is the Empire State Building. He's very interesting character. The last I saw him. I was watching something on Instagram. I saw him in a sauna with oven mitts on riding a bike like one of those Echo bikes like those Rogue, you know, those aerosol bikes riding one of those fucking things in a sauna. I was doing his sauna routine I did.
Not like it. I was cranking the song up to 220 degrees and I think I cooked my lungs a little bit not bad, but people who listen to the podcast afterwards my apologies because I was I was coughing like that for like four or five episodes and then I had decided. Okay. This is fucking stupid. Like I don't think this is good for me. Right? Well, you know hormesis. Yeah, what doesn't kill you makes you live longer that's not exactly true. You can push it a little too far sometimes. Yeah, but booze booze doesn't kill you, but it definitely doesn't make you live longer. That is true. If you drink hard every night kill something my shit. If you look at two people one that drinks hard and their brother who just drinks water and runs all the time boy that water drinking guy looks fucking fantastic doesn't he? Hey comparison. Well, yeah, that's probably another one of my vices. I got to lay off the alcohol. Who's yeah. Well, how much do you drink? I'd probably have one or two a day when I'm on vacation like you I overdo it. I just got back from vacation. It's my body's way out of shape. Yeah I get
Fatima Acacia, man last time I was on vacation. I was doing this. I was grabbing my size. I was in Italy I went hard I was drinking wine every night wondering about a half a bottle of wine every night. I was eating pasta all day long, but I'm on vacation. I just go fuck it. And also I kind of gives me a little project when I come back, you know, like all right. Now it's time to get serious. Right? Right. Well, I was in Africa recently and I've got to tell you one of the when you see a wildebeest get attacked and chewed on for 45 minutes by a crocodile. Nothing better than going back to the camp and having a beard or to calm down. So I did a lot of that. So when you were on Safari, how did you when are you in one of those open Jeep deals? Yeah, a lot of that. We did also some hiking we had Maasai leaders that would go out and with a Federal Officer with gone to protect us. Oh Christ. It was fun. It's so much so different than being in a jeep to walk.
On the cats. Oh, yeah, man, you gotta sure you're almost dead. Yeah, it's just like you're right there you feel like you're alive, you know how you get the feeling of what it was like to be an early human. I've never encountered anything other than bears in the woods that are terrifying. I've never seen a mountain line Y like hunting. I've only seen two mountain lines ever one was from my back porch in Colorado and one was in the street and Santa Barbara. I was driving and I saw one run across the street, right? I didn't realize it was a mountain lion until I saw the Tails like oh shit. I thought it was a coyote or something. Then I saw that long tail but while hunting I've the only thing I've ever seen as a grizzly bear so a grizzly bear wants I've seen black bears black bears are unnerving grizzly bears are terrifying they look at you like this. You could shoot him and they'll still come. They just look right through you they look like am I eating you what's going on with you? I'm going to eat you like they're trying to black bears a like. Oh, should I get out of here? Should I run? Am I the boss or you the boss like they're not sure.
Grizzly bears are fucking sure. They're the boss who's trying to figure out whether or not they should eat you right now actually one of the things you realize when you're amongst these animals. It's a huge privilege for us to go for a walk without getting eaten. Yes. Yeah, we don't think about it that way because we're so used to being in parks and oh, I'm out nature the fuck you are you're not really in nature here in some weird sort of Nature Preserve that we've sort of set up inside cities, right and people ask me about my work. Oh isn't what you're doing. Unnatural. Fuck natural. What about our weld is natural. Anyway brushing. Your teeth is a naturally they're stupid. Right what you're born with a toothbrush in your hand. Shut up. Right? Right. Well, I would down flew over here water at 30,000 feet drinking a cocktail surfing internet and also natural that's natural. You're getting bombarded by solar radiation your boozing it up your also somehow or another online. No way that anybody is ever going to be able to explain to me that my puny brains can understand right? Yeah. Exactly. Well, yeah, don't give
The argument that aging is natural therefore it's acceptable because I don't buy any of those natural things because everything on Earth is natural even chemicals there is no we're not getting them from the Stars. We're not pulling them out of the dimensions. Like what are you talking about? It's all from Earth everything, right? Even Paul ceuta calls most of them have derived from Plants. Sure in Africa is hanging out with but what tribe these are the pygmies they used to be in the forest and I had the chief take me through the forest and he's showing me all the drugs they used to take there's this clustered in IAM. I think I'm saying it right it was a leaf. They used to chew on they'd smoke a bit of weed. They'd go a little dizzy. They crouched down after about 15 minutes, they'd stand up and they felt Invincible, they'd go kill one of those elephants in the jungle Jesus. That means killed elephants. Yeah many elephants. Oh the smaller elephant. Yeah, but now the kind of smaller people rights old meanie out. They can't accept the worms the worms were about this long my buddy Justin ran. We're a big supporter of fight for the Forgotten charity. It's a charity that my friend Justin run setup and they
Well, so the pygmies the Congo and through this application called the cash app and I've personally donated to and we also we're doing benefits for them. We're doing a big benefit in La coming up soon that will be announcing soon. But he goes over there all the time and he's had malaria three times and just recently has acquired some unknown parasite that is just devastating his health. He's trying to figure out what it is. So he's got to go through a battery of tests and they've got a you know examine him but next time it goes over there. Apparently, he's going to bring his own food but mean the fucking poor guys got malaria three times. Yeah. Well, you should be taking his medicine more often I think but they'll know it reoccurs. Does it really obvious not get rid of it. Well, it's it becomes systemic right? It's horrific man, and the way he describes it and he's a gorilla. I mean a fucking gorilla. He's a huge man. He fights for Bellator. He's one of their heavyweight contender.
So he's this, you know, 250 pounds stud of a guy who goes over there and catches these horrific diseases and just like barely survives Right company gets the medication and comes back. But then when he gets sick, sometimes it'll kick back in again. It's kick back in twice another reason. We don't want to go back to natural way of life, but you're a good man Joe for supporting the the pygmies. I was just in a such a fucking angel when you you talk to him and you you see his documentaries that he's put out in his films that they've done with water for and now just with his organization fight for the Forgotten like you can't help but help. Oh gosh. I was in on the Ugandan side of the volcano Rift and the way they live was just it was shocking and we're going to help rebuild a school for them, but they need help and the right on the edge of civilization the Betrayed the pygmies are in the worst situation than anybody and there.
They're the lowest of the low they're picked on racially. They were kicked off their land. Yeah to save the guerrillas in these elephants and I don't know what to do. They've got they everything they knew how to how live is gone and they're crazy. They're kicked off their land to save animals, right? Yeah. Well give it there's no there's no way out you got to do that. Well isn't there a way to not kill the animals and have them all coexist. I guess you could have kept them in the road. It's a national park. So you can't easily have humans living the national park as suppose you could but they are trying to modernize them. So they put them on this small few acres of land which they're trying to learn how to farm and the way they subsist is through tourism. So I would recommend anyone who's interested go see them support them by a lot of stuff. We I think we bought up quarter of the village they love that but we're going to go back and do something meaningful. That was awesome.
That's awesome natural. So we were taught we go with off sidetracked. So you were in Africa, which is the most realistic environment. I mean if you want to really know what nature is all about you were in the most realistic environment. It's all tooth Fang and Claw. It's like whatever survives survives and whatever doesn't becomes food and there's just this constant cycle going on and you're walking around. Yeah. Now when you walk it up, will you walking when you saw the crocodile eat the wildebeest know you're in the Jeep? I was in the Jade for that. How does a Jeep thing work? Why don't they just jump in the Jeep? I don't understand that good question and I asked myself that as they'll walking by same with the gorillas. I've been habituated to humans. They literally don't even see the Jeep or the gorillas. Don't they're you know, they're not aggressive unless they think you're a threat they don't eat meat they're just eating plants all day. Yeah, they're still pretty dangerous One swipe from a gorilla. Oh my God gray back with
Back up. It's interesting that the Jeep's have been around for so long. They just go under the Jeep. There are going upstairs. Yeah. Yeah that it's as though the Jeep's aren't there. You might have six Jeeps looking we saw some lines rip apart o Impala right in front of us and they just going about their daily lives. You see it catch. It just missed that. We saw them running away from God. If I saw them running in real life, I'd shit my pants without running towards our camp. So we're running now the way I heard a horrible story about these people they're on Safari camp. And this person went to use the bathroom in the middle of the night. Apparently, you know, there's cabins and you have to leave the cabin to go to the bathroom and the cats went in the bathroom and got them and drag them out the kidding. No, that's the worst way to go. Yeah. It's the hyenas you got to watch out for because that'll actually Eat You Alive. Well, fuck. Yeah, but the locals don't like the hyenas. They don't have respect any animal that eats another animal. Well, it's
Screaming. Oh, yeah, they don't give a fuck. They don't try to kill you. They just eat. Yeah that wildebeest had a broken leg. It got away from the Croc, but it was it's Bush made at that point. Yeah, but there were people in the Jeep some other Americans cheering. It was like a sport for them. Oh, no, I didn't appreciate fuckin a man. It was a solemn moment. This animals gonna die and they're like woohoo. Yeah chasing. It must be men. Right? It was mixed. It was girls I'd be super concerned. Although I think it was a few but girls were cheering. Yeah. Fuck him might have been I think was the guys cheering but hard but that would chasing this poor animal. It's Holford been broken off and it was running on a broken leg and I would chasing it the people are the Jeep and people in the back of the Jeep. Yeah my kids with me they were screaming and crying it was it was emotional and I want to see you. Yeah. Yeah. I I've never seen anything take anything out in the real world. It's shocking, you know, you can see it see it on BBC.
Never as much as you want when you see it live my friend Johnny Hamilton. He works at a ranch in Colorado shot out to Johnny. He was following the trail of this gigantic elk. They'd seen all these footsteps and they seen mountain lion footsteps and then there was no more mountain line footsteps and then they followed it about a hundred yards of show or so and they found the cat the cat on top of the elk. It had jumped on the Elks back and killed two elk as a hundred fifty pound cat a 900-pound elk a big bowl and it just leaped up on its back and just like and got a hold of its neck and neck and dragged to the ground but it rode it for like a hundred yards. Yeah the Croc did this to to the wildebeest. Yeah. So elephants are interesting. We saw a lot of those and what we learned was that the old elephants because they've run out of their teeth their teeth wear down and at some point they just can't chew anymore. So they have to find really soft stuff. Eventually they die and that gives rise to this.
Legend that there's this graveyard For Elephants. Not a graveyard is just where the soft food is, but I was thinking if elephants had technology they could easily solve aging they just get dentures and yeah, why can't we just track them and give them some implants? Yeah. Well they do it with people right and I think in the zoo, they might do something like that hide my they do a dog my teeth rebuilt. They'll wearing out. Yeah, I've seen that before with people it's cool. It made sense. Like it's my daughter's teeth and that but I said to the dentist I know changing topic here, but with it's funny I said at the dentist. Can you fix my teeth? You just did my daughter they went on. Oh, you're almost 50. We don't fix T that 50. Excuse me. Do I feel like you're on your way out? Exactly. Yeah. Someone said that to me when in terms of meniscus, I had a meniscus tear and they said well when you're younger you have more blood flow to your meniscus and we would just surgically repair it and hope it would fix or perhaps today. You stem cells but most likely.
Likely because of your age it's not going to heal correctly and I'm like, okay, I'm confused because you're talking about blood flow like blood flow. Like what is happening? That's different. I don't I think this is like some old medicine nonsense like is blood not flowing. I mean, well, it's flowing and someone with your Fitness is Flowing probably as much as a 30 year old. Anyway, I'm in better shape than I was when I was 30. I do more shit. I do more running. You know, I'm like Mom, I got a lot of blood flowing around man. I'm I'm I think they compare you to sedentary people for sure. They do that's the problem with most medicine is that it's tailored to the average person. Yeah, we got to fix that. It's got to be personalized tailored. Yeah measured. I think if I wanted to go on Safari like that like you did I would have to make sure that I wasn't around any cheering assholes like that. I got I would have to take some sort of a solo trip and I'd have to be heavily armed right and then wearing armor some sort of armor. Well, so that wasn't engineer and a flamethrower. Yeah.
They're with me. Right right, fuck those things man. You never see Survivorman. Do you know survivors? Yeah. Sure. Yeah less is a great guy, but he's committed to finding bigfoot' now it's always doing these days, right? Yeah, but anyway less did an episode where he did Survivorman in Africa and he the scenario he would create these fakes and arrows, you know, just man-made scenarios, like what if you were in a hot air balloon and the hot air balloon got a hole in it and crash landed in these lion infested territories. So he literally did that that's insane in the basket. So he had a few items in the basket and the the flamethrower for the for the hot air balloon with him to ward off the fucking Lions. So here he is. It's nighttime in Africa. And by the way, he sell films everything, you know, the reason why they came out with that other show with that. Who's that other dude?
The other dude that got busted like sleeping in the Holiday Inn. He got he's really going to the yeah Bear Grylls. He was going to the Four Seasons at nights like this is how you could do it, but I'm not gonna do it. It would show you how to do it. You could sleep in an igloo, but meanwhile, he would fucking right he was getting room service and eating steaks and shit. Yeah, that's what I do but less Stroud really does it. I mean he brings a series of cameras. So this is him and last went and he so that he pretends the thing crash-landed. So this is the scenario that he's created for himself, but the reality is he really is surrounded by lions. And so he has a limited amount of propane and he would fire up look at look. Look look he would fire up that thing which is what you use to get in the hot air balloon and scare the shit out of lions. So through the night. He react you would hear that look at those are the fucking zebras and shit. So he'd hear it in the middle of the night and you have to fire that thing up to scare everybody the fuck away and then after an hour,
Our so that my off fuck time to fire it up again. And so he was out there sleeping in this basket trying. Yeah so crazy. He's so crazy and he would also do these things where he would have virtually no food for seven eight days, you know and just really just get super super skinny and almost starved to death. That's the opposite of being in a jeep. He's got like a bottle of water. I got a pocket knife. I got some rope like this is how you do it. I got a stick. What is that all some sort of a machete type thing fucking crazy. Yeah. We went up in a balloon which was beautiful by the way, it's fun, isn't it? I didn't Italy recently Italy wild. Yeah, it's anyone who's afraid of heights. Don't worry. It's beautiful, but we had a truck underneath us with people with guns just in case that happened. Oh, that's good. Yeah, so they've got to take a long people. Yeah, there's also industry and keeping people alive that want to do stupid shit. Yeah, probably right you can imagine all sorry the Serengeti burnt down yet with some guy in a balloon.
How many days right how many days did you go there for we traveled for 16 days. I took my whole family. My little brother is kids. How old is the kids two nephews and my kids are 16 14 12 perfect age for this and they don't recommend you being under a certain age. If you're going to take malaria medication, right? They hold it whoops. Really? I don't I think 12 might be okay if I think it's like under 10 or something like that. Well, there's you know, the stuff is heavy duty, like didn't fuck with you. Did you have crazy nightmares? I took the one that doesn't give you nightmares, but my other siblings had that my father came so he's 80 and that was actually the reason we went to his 80th birthday present. Oh, wow. That's cool. What a cool present. Yeah, I'm days. It was it was awesome. We went our Kenya Tanzania Uganda with what did you like? Best Tanzania supposed to be gorgeous? Yes, Serengeti was incredible. It was all good. I really liked hanging out with the with
And beings to their interesting species off for sure. Yeah. I enjoy humans. Yeah, I thought was the origins journey. I called it. And so we went to we started in Olduvai Gorge, which is where humans the the original fossils were found going back a few million years. Wow and started there and then just went through looking at the various animals. We saw the gorillas and we ended up a few days ago. I was in Jerusalem looking at where we come. Oh, wow real Origins tour. Yeah up there exciting again. That's exciting. Wow. That is so cool. So what was the most unusual thing?
Besides Jerusalem, is that the most unusual? That's the most insane thing where all the religions are on top of each other touching rocks and blessings spraying and humans are crazy. They'll worship anything. Well, I'm sure you've seen I was in Germany wants and therefore a UFC and I was flipping through the channels on the television and there was this live feed from Mecca.
And this is pre Instagram. I was on Instagram. I would definitely would have because I watched it for hours. I just sat there and my room drinking a cocktail with my feet up watching this these people circle around this. What is that square shaped thing in the center of Mecca? Yeah, if you get was it religious object that I believe I think says something to do with an asteroid like there's a piece of some find out that makes sense is important to people but they the watching people Circle they're all wearing the religious Garb this Islamic Garb that they have to wear and they're all circling around this thing like for hours and hours and hours one way It's oddly appealing like part of you wants to go I recognize that there's got to be a very strong sense of unity and community in everybody agreeing that we
Are all going to treat this this is a sacred object is a sacred place. We're going to wear a sacred close. We're all going to follow this this path in this and we're all going to be together in this like this like super reinforced sense of community. That's actually ordained by God himself. Well, we all need that feeling for for me. It's science and the fossils that I and my colleagues believe with the origins everyone needs an origin story. Here it is. How would you say that cut? Kabaah? Kabah? It's built around a sacred Black Stone a meteorite. The Muslims believe was placed by Abraham and isma'il Ishmael in the corner of the Kaaba a symbol of God's covenant with Abraham and Ishmael and by extension with the Muslim Community itself. Hmm. Okay. Yeah that there so it is it is actually a meteorite which how incredible right like a little bit of Science and a little bit of religion all wrapped up together this discovery. So this this is
It looks like so you're watching this the Channel that I was watching in Germany again. This is probably like more than 10 years ago 12 years ago, perhaps and watching this circle around this.
Like religious spot very very captivating. Yeah, the one that I remember most from I think was Jerusalem. Yeah was people touching the stone where the crucifix was thought to be in the wood lined up for hours to just touch it for a few seconds. Meanwhile, the origin of humans the fossils. There's maybe two or three people hanging out. No one really cares admittedly. It is out of the way. It's not in the middle of the Middle East but still it struck me that humans are more focused on these icons of religion rather than where I believe we really came from Africa. Yeah. I mean if you look at it and you see it you touch it feel it. It's the only sensible explanation. I mean you can still have religion that's fine. But you know, don't tell me those fossils were put there by somebody no, I mean obviously not but it's it is that the idea that a human being came from some lower hominid which came originally from a shrew is so so hard to follow
Like if you go all the way back to 65 million years ago to the asteroid hitting the Yucatan and you're like wait what happened? Oh, yeah, big rock smashed killed everything except like these little rodent things and they just eventually evolved. Yeah, but that's what I love about science. It's amazing. It's not only amazing. It's actually true. Yeah, we can prove it. Yeah, I mean basically pretty good really follow the fossil record. That's one of the funny things when people go oh, what about the missing link, there's missing there's holes in the fossil record. Well just holes in your education. It's not holes. I mean, they go out to Australia Pittacus. Explain Australia Pittacus extreme explain explain the various other human beings, you know experience explain homo floresiensis explained the Neanderthal explain all these different there's a whole slew of different fucking things that were human. Like, what was that God's experiments was God fucking around. Yeah. I was like, let's try to make them super short and wide and
Thick and heavy like a five foot seven 200 pound person. That's way stronger than a person to add. Those are no good. Listen, let's get a taller skinnier one, but with bigger brains. Aha, right and let's have them breathe. That's what we did. Let's bang them. Yeah, everybody bang. I don't know if it was marriage or right but something happened I think most rape mostly most breeding was rape until about like 500 years ago. I agree with you. Do you know that to this day there's a country is it Kurdistan?
What is the there's a country that twenty percent of all marriages begin and kidnapping?
So there's a shame to the female being kidnapped. She ultimately has to marry her captor find out that's is it Curtis tanker Kyrgyzstan. I'm not saying it. Yeah, how do you say that Kyrgyzstan argost and I think it's Kyrgyzstan. Yeah one in five girls and women kidnap for marriage in Kyrgyzstan. How fucking crazy this is 2019 religion, right? Yeah shame but the fact that you could kidnap someone rape them and then they get shamed into marrying you well, I was shocked in Jerusalem. I'm going to probably have a lot of hate mail for saying this but it's a fact that when you go to the Wailing Wall as I didn't put little note in the wall, which was a great experience. By the way. There is a space for men and women are separated. But the space for men is four or five times bigger than the one for women good couldn't help myself. Yeah, it's all this disparity anyway, so so early
A similar amount of women that are going through this wall and they're just jammed into a smaller area. Yeah still 2019. Is this some ordained is this some sort of a religious? Yeah, the Orthodox who apparently behind that I checked it out. So there's there's an actual scripture that says men are supposed to have this - I doubt that so it's just ancient sexism. Well, yeah and even the wall is just tradition. Yeah, right. But anyway, the history of humankind is interesting and I did that because while we're out there what's all the black spots that's like coals Grass at sick plant material. I think is it yeah. Yeah Doug plants growing out of the wall. Well, so it is okay. They're not black. We're just looking at low resolution. That's the women's side. That's the men's side. Do you remember the scene in?
What is the World War Z when all those zombies climb up the wall? They pile on top of each other. Like do you see World War Z? No fucking great movie. Like I said it is there's a crazy scene. It's Brad Pitt zombie movie where all the all the zombies pile up on top of each other and make it to the top of the wall. You got it. James going to pull it up, huh? So they get to the wall and look at these fucking zombie. People are climbing up. Yeah. Yeah. Oh, it's pretty gnarly man. You never seen this movie. I've wanted to does the novels are supposed to be excellent what the novels written by some famous guys, son.
Who's who wrote the now but there's a great scene like see they're all piling on top of each other and there they just Reckless they have no concern for their health or well-being because they're you know, look they're dead. So they're just making this human thing and then the soldiers are shooting into the pile trying to knock them down, but they get over the top of the wall and they start infecting people.
It's pretty wild as movie. Yeah, who wrote that movie?
This is a wild movie man. This is what it's one of those zombie movies where the zombies move fast that this is slow zombie movies, which come on man. Like that's why Walking Dead. Like I feel like you could fuck those things up. I mean they can only last so long they don't move fast. Like how are they surviving? They just kind of like shuffling towards you I feel like if you just have a big sword you can just start hacking away. Yeah, so there are some B cells in the body and I make that segue because people going to say why the hell are we talking about aging? Well, we will okay. We're here forever Max Brooks the son of Melbourne Ah-Ha. There you go. Shout out to Max Brooks and Mel Brooks. Sorry aging. Well, we don't have to Zambia cells. Yeah. So what are they? We don't talk to my man forego and your trip she'll show because it's pretty exciting. It was your show to thank you when you're on it. Yeah grandpa. So well something else I recommend everybody go to Africa.
Just come back a different person. I better human being but also to support them. They really need our help over there. When you were in the area where the oldest human like fossils were found. What's the feeling like when you're in this are like you really are where the origins of humankind or from? I mean that is got to be a pretty profound feeling. Yeah, it was spiritual. Unfortunately that the people who drove us they were saying, how are you how are you have to go see some zebras like this is more important than the zeros but these are the people that are the guides. Yeah. Yeah. They don't know what was important to us for enough but I would have loved to have spent whole day there. They apparently there are still fossil sticking out of the walls of the Guerrilla. Yeah. So the reason that it's a be allowed to do anything with them Donna what happens if you find a fossil yes to contact the university just like shut the fuck up. Well, actually I probably shouldn't confess this on don't live me don't do it.
Tell me later. It's not so bad. Okay, you can actually find a whole bunch of stuff in Africa. That's interesting. If you look down rather than out and my oldest daughter our oldest daughter Alex. She looked down. She's a scientist. And so she 16 year old scientist. She found a whole bunch of stone tools. Whoa not they're not not in Olduvai Gorge that sacred but, you know, just out on the Serengeti or wherever did you get them analyzed not yet?
He recently found stone tools in the United States that they've brought back to 16 thousand years ago the oldest known stone tools of any human being and it's sort of their there slowly but surely pushing back the dates of human civilization in America and one of the more recent discoveries with stone tools that are from 16,000 years ago. So people had made their way over here or there it is. What does it say about this? Yeah, so you never saw it. I don't know if you saw it yet. They said it there's I don't know if they have video of it, but they said they saw this monkey sharpening that's done before it was actually breaking the glass with it Mama shatters the glass with sharpened Stone impressive Prison Break attempt man. Fuck keeping monkeys in a cage that drives me so crazy. I hate it. I went I took a pot edible once like a real strong one and I went to the zoo. It was so depressing staring at the chimps as
Cross and watch the chimp cage. I'm like, oh my God, these things are in hell. Yeah, they're just in prison even keeping little birds in cages little cages like this. Yeah, but the monkeys are waves worse right there wailing where they had some some type of monkey. It was in a smaller cage than the Champs. It was just wailing. Wow.
Just inhale. Yeah, it is. It's brutal. Actually that the the stone tools are interesting because again getting to what's natural what's natural for primates is to change their environment to take tools to yes. So what we did what we're doing genetic genetic engineering. Well, I want to engineering but we're using genetically just and why we aren't why we agent why we don't have to it is natural. Of course. That's what we do. All of even all of science is natural. You could even argue that an iPhone in your pocket is natural sure humans have created it they exist all over the world. Right? I've argued that cities are natural. It's a completely normal thing for humans to do to create cities to say that cities are unnatural. Well why they everywhere and why are human beings making are saying beehives are unnatural to write a clothes? Yeah, unnatural. Well animal habitats mean animals, like beavers create beaver dams and they're very uniform. They're real similar everywhere. They go. Exactly no. Yeah the other day I was someone said
Humans timed fire 500,000 years ago and I said that can't be true 500,000 years ago. That's too long ago. I checked it out. It's true. And these weren't even humans these or pre-human. I think it was probably one of the two species back. We've been doing this. We've been changing the environment using tools using fire for that long the fire when it's crazy right because it's not just manipulating a physical thing. It's changing the state right you're doing something whether it's with flint and steel, you know, some something to spark and some tender you're really creating changing the state of matter.
Well, we are and will continue to do that will continue to evolve and one of the the reasons I wanted to see human Origins is in my book. I talk about we've evolved to our natural lifespan. We now a maximum hundred and twenty-two is the longest live human that ostensibly is on record the so without intervention we've reached our maximum, but why not now give us what evolution failed to give us? Why can't we be like other species that are at the top of their game are there any factors when you look at the oldest people that are alive are there any common factors actually not really that they do seem to have a collection of Gene variants that predispose them to get to that long. There's one called Fox 003 that if you've done your genome we can have a look 23 and me that you've done it. I have we should look at it. I'll just tell you you need an A or a tea at a certain position. I've got one of them out of to my kids got two of my kids out of three have both so they if they look.
Themselves might have a better chance of living longer. But anyway, these long-lived people they tend to live a long time no matter what they do often. They smoke till 90 years old. Really? Yeah.
The quit at 90 there's a few cases of that and they live another 12 years. Right right there for 22 years, right? You said a hundred twenty two years old that right? That's one one lady in France. But I one of my friends here is his name is near barzillai when he was with me and Israel. He's got a story of when he asked the centenarian lady lady that lived over a hundred that he knew why didn't you quit smoking and she said 0004 doctors I went to told me to quit smoking and they've all died. So keep going. That's hilarious. What did she do for a living?
John Coleman, I forget the French lady. I don't remember what she did I would imagine that would play a part like how stressful your occupation is. And yeah, she had a great sense of humor that was probably part of it. It's used to make jokes with reporters all the time one was how many wrinkles do you have? She's as I've only got one and I'm sitting on it, but the other one I think is even better as a reporter who was young said, you know, you're a hundred and sixteen. I hope I see you next year for your birthday. She says I don't see why not you seem pretty healthy to me. Wow, and she made it to 122 now have there been any anecdotal reports of people that live longer?
Well with those Lauren Biblical times and not biblical like not unsubstantiated reports of because I had heard of either some people that claim to have lived like ridiculously long, but they've never really figured out whether or not it's accurate sure. There's there's a few of those but even even John comment at 2222. There's a big argument now between us researchers whether that's even true. Oh really? Yeah. It's a massive debate. I've got an inbox full of long angry emails from scientist. What's the evidence point to the contrary that too? So the hypothesis is that she her identity was subsumed by her daughter to avoid paying taxes and as photos of them and there are there's a blotch on one photo that matches the daughter. So there's a lot of forensics going on and if you want to subsume the grave and the French government's not or French researchers aren't giving up the blood samples. They don't don't don't want to know so it's probably horseshit.
Well, probably like a hundred years could it could be bullshit. I would say it doesn't actually matter goddamn French. It doesn't matter people have lived a hundred Seventeen and that's still pretty good. That's what we you know, if it's in the we can all live live that long who's going to complain wouldn't you like to get one of them old old old old old people and start doing work on them? Yeah. Just pop them up with NAD get him on a drip. Well, my dad's experimenting on himself. So he's nodding hundred yet. But he's 80. How's he look? Well, I wouldn't say looks young but his Fitness is like a 30 year old and really he's stronger than me. We tested out in the gym the other day. No way. That's embarrassing. He can lift more. He's fitter. We're going across the Serengeti and he was leading the charge if you saw him if you didn't see his face because he's got gray hair and whatever physically he put a bag on his head. You'd just you'd say is 30 the way he moves very where to put it back in your dad's head. Yeah. I shouldn't do that. Sorry Dad, but he would think he's 30 really? Well, he's reinvigorated in life. So, you know in my family
We've got some Ashkenazi bad genes. We tend to Die Young and my grandmother died. My grandmother is actually only 15 years older than my dad and she died two years ago last 10 years of her life horrible. So we know what's going to happen in my family probably to all of us. We don't tell your mother your grandmother had your father when she was 15 years old, right? Whoa. Yeah back in the early days of World War Two. She apparently was playing around with her boyfriend. She claims to be a virgin but at that point but something got somewhere that shouldn't have and she was during High School, right? So I was raised by my grandmother. She was in her 40s when I was a kid and she was the one that taught me to always stay young keep your Adults Ruin Everything. That's probably why I work on Aging that's it Harold's ruin everything. We're hot. What was her advice like in terms of like why how do you avoid what adults are doing wrong?
Well, you know she'd grown up during the Depression and then World War Two and then the Communists came into Hungary and raped a lot of people she had no she had no respect for Humanity. So by the time I came along first of all, she put all of our energy into to me and I'm I was a spoiled brat as a kid. So that that was wasn't helpful to me. I think now as an adult but more importantly she wanted me to do the best I could with my life. She said David do what you can to make this world a better place make sure that you leave this place better than you found it and that's what I'm trying to do. Wow. What a profound and piece of advice for a grandchild. She was a rebel. She taught me forget the rules. All right kind of like you do. It's I'm going my own way and we'll see how this goes. She so she went to Australia. She said fuck Europe. I'm out of here. She went to Australia the furthest place you could find from
Never went back. She went on Bondi Beach in Sydney in a bikini which was rebellious known as she got taken off the beach by by the police. Would you have to worry about that are the full little British thing deep down. He's what it o down to your knees. I think so too. They look like maybe it was a full one piece, but it's only show your belly. That's what I think but she was a rebel she went to New Guinea by herself in the 60s. What year was this where she was wearing a bikini? That would be 56. You couldn't wear a bikini in the 50s. Wow.
While okay, like those pin-up girls right when you see them. They always had one piece suits on like yeah. So imagine you Guinea in the 60s as a woman on her own. I live in the highlands. She claims to have eaten human flesh. And so she spent most of the time drunk as well. Did you see that article that was yesterday where they were interviewing an Australian a guy who's a doctor or a scientist who's talking about climate change and he was saying that we have to start eating human bodies and that human bodies are very nutritious and that we just put them in the ground and the it I was reading it. I was like, okay is this kite rolling? Like what is what is he doing here? Is he a completely insane person? But his advice was our dependence on meat is ruining like in some places where they're you know, they're stripping the rainforest to make room for cattle grazing. He was saying that
We are getting rid of perfectly good meat every time we put someone in the ground. Well we are but but to suggest that is sounds insane to me. Yeah, because we throw away half our food. Anyway, at least in this country. It was a mainstream publication that this guy was talking about is like the last thing you want to encourage is people getting used to eating people. He's been watching World War Z may be. All right. Yeah. I mean, it's just one of those please mate, but come on I was I was going is this guy just trying to get attention like the seems like such a whore is it that he was he joking and it's hard to tell in text, you know? Yeah. Well, yeah and you said that not every Australian is sensible. I found the article but I don't see anything about him saying wasting human bodies or meat. It's been a more than several articles written on it. Maybe somebody extrapolated but the idea was he was saying that people should eat meat and if they want to eat meat they should eat human because oh well, maybe the waste animal rights activists might be just an idiot your relatives. Yeah. Yeah, but you
Last thing you want is people getting the taste of people, you know right now, I do not need to go that far not yet speaking of the food supply one of the things people worry about if we all live longer is we're going to run out of food and run out of space. Yeah, and one of things I address in the book is what really will happen. If you do the calculations, if you look at human history that is not going to happen. I'm of the strong belief that we can engineer our way out of just about any problem. Probably. The only thing we can't engineer our way out of is if we get hit by a five-mile wide meteor, right but everything else I think we're going to be using climate change. We're going to be able to engineer a way out of well, I don't think we can stop climate change at this point. It's definitely happening. You can see it all around but will it wipe us out? No, it will it cost us trillions of dollars a year. And so I don't think it's going to be the end of us, but it's going to be a challenge to continue to survive and proliferate.
As a species in the face of all of those costly things and that's the biggest problem of climate change besides species losses the expense and the Euro, there's only certain amount of human capital that we have to spend and we call it money and that's one of the reasons that I'm excited about extending People's Health and life span is that that will save tens of trillions in the globe each year and that's money that can be put to combating global warming saving species besides, you know, wonderful people who donate their their earnings as well, but really to solve the big problems in on the planet one of them is to solve what we can do with all the frail elderly people that are coming every year more and more.
Let's make them productive like my father. He could be in a nursing home like his mother was whereas now he's hiking in the jungles looking at watching Gorillas with his five grandkids. How cool is that? It does pretty cool know. What kind of protocols here on pretty much the same as me. Although he does more exercise. So it's a combination of Hanuman metformin and Resveratrol.
And what kind of exercise I'm not sure if his protocol we're going to post that on on social media once we're sure it and but I know it involves a fair amount of aerobic exercise. He does rowing and and walking up stairs. So he managed to climb. I think it was 40 stairs in 50 40 flights of stairs in 15 minutes, which for an eight-year-old was was quite a record any flights of stairs and 15 minutes. Holy shit. Yeah, the guys have phenomenon. What what has happened though is that his outlook on life has changed. He was depressed. Not not just because he was fearful of getting old. My mother was sick at the time. But now he's looking forward to another 10 years of vigorous life traveling and it you know, when you're healthy you're happy. So when he was depressed was he sedentary?
No, no, he was depressed because he was worried about his health. He figured he's gonna be like all his other friends getting frail can't can't walk losing your mind and it hasn't happened to him. So he just a few years ago. I went back and started a new career. Whoa. Well we talked about this last time I believe what's his new career again? He's on a committee that evaluates clinical trials for ethics. Wow, which is what you want older people to do use their wisdom and knowledge to excited about something as well write something that stimulates you and keeps you going and gives you something to be interested in and talk about wasting human flesh. What a waste it is for someone with that knowledge to die prematurely, right? That's the more interesting thing to me about longevity is look I'm so much wiser at 52 than I was at 42. I just am I make less mistakes. I'm more aware just across the board and I'm wiser 42 than it was at.
And at 22 I was basically a champ. So it's like as time goes on you understand how your interfacing with the world you you communicate with people better, you know how to get by you know, what you have to do and what the consequences are of not doing what you have to do in terms of being disciplined and being healthy and just meditation and making sure you you understand the consequence is also of not doing the work that you're supposed to do in terms of like the way you feel about yourself your self-respect and the way you just feel about like your sense of self-satisfaction. It's it to me takes a big hit when I'm lazy takes a big hit when I don't get things done and I don't expect everybody to do the same things that I do or have the same sort of work ethic or nuneaton. I don't even say work ethics that implies like some sort of superiority. It's more of a
Just the idea of what you want to accomplish like your tasks. Everyone has their own idea of what but if you enjoy doing something and you're working towards something I feel like
There's more purpose to life. You have more satisfaction in accomplishing tasks. And that's one of the things that's been highlighted. When you read books on happiness and studies on happiness. One of the things that seems to be most important is goal setting goal setting working towards those goals and achieving progress, but these are critical components to happiness for human beings. And without them with is this aimless sort of drifting of life people for the most part obviously everyone's different but for the most part people don't find satisfaction and just a nameless sort of drifting existence. Yeah hundred percent. I'm I just turned 50 while I was over in Africa. I'll just before that, you know, imagine being 80 and healthy that like my dad ninety or a hundred it is so good. Of course, I'm so less stressed than I was in my 20s and 30s and anyone who's listening who's in their 20s and thinks that they're you know way better than a 50 year old. I can tell you from experience like you Joe when I was in my 20s, I
I knew everything or at least I looked at myself as as a 50 year old and I thought what an old fart. Yes. Yeah. It's not like that at all. Especially with today's health and 50 year olds are just like they were like a 30 year old was there was you know, fifty two year olds like me when I was 20, they didn't exist. Maybe Jack LaLanne, right? Well that it's being talked about I think was in the New Yorker that this movie Cocoon. I don't know if everyone seen it but it's a pretty interesting movie where these 50 60 year olds. Are we given the Fountain of Youth and they still look old but it was really supposed to be quite funny to see these older people with gray hair jumping in the pool and acting 30 years old but a 50 year old isn't old anymore 50 rolls. Just getting going. Yeah, that's crazy about it. You know, I mean if you see old movie stars from like the 1960s when they were like 50, they looked like they were dead men, you know like we were
We're looking at I forget what the movie was but it was a movie where I was like, how old was he when they made that movie it turned out. He was 44 like that guy looks a hundred years old looks like he's never worked out. He probably smoke cigarettes all day long never exercises never drinks constantly. This looks like a dead man. It's crazy. Right? So so in the future 90 will not you will feel like 50 and full. We were talking about Laird earlier and layered I think is 55 years old and just as fucking fit as a human being can be and he's doing crazy shit where he's got this whole exercise routine that he does inside the pool where he brings like 70 pound dumbbells, and he carries it with one arm and swims across the pool and the other you know, he does two-handed dumbbell things the bottom of the pool and leaps the surface catches a breath of air drops back down to the bottom again leaps the surface. Why is carrying these dumbbells. I mean just ruthless rigorous exercise at 55 years old well that they'll be a time when you
We tell how old somebody is, especially when we figure out how to reprogram the body to be young again. Yeah, it's going to be such such a great world when people with 80 years of experience can continue to run companies and be teachers and educate the young people now that there's a bias though against the elderly. We've always had this in society and we have to overcome that my dentist was biased against me as a 50s and I want to fix your teeth. You're dead bro. Not fixed not worth the money screw it. I'll pay for it just do it. So it says a 20-minute argument do it do it 20 minutes. It was a lot in fact the time ran out and she said fine. I'll do one tooth just to check because she was had all these reasons why shouldn't a little break off. I have to polish back your original teeth. And I said, look, I'm not going to get angry. If it doesn't work. Just just try it and she did it. And at first of all, she said I have to eat crow after it and then my wife came a week later and she said man your husband's a pain in the ass, but he's onto something and actually she's offering this as a service now to people our age. Yes trying to make money I guess.
Got it. Fuck it hasn't cracked off and I'm pretty happy with teeth that if it does fix it again, right? Why not? Yes everything and we should do that. Yeah, but here's the problem with with some aspects of medicine when we're young. We don't get the medicines that will prevent us getting sick. When were old. Yeah. So drugs like metformin you're not going to give to a 23 year old right, but when you get old, you don't get the medicines that they give the young then everyone should be treated equally in my view as long as we know it's safe for sure, you know, there's the cost but some of these treatments like metformin that's probably less than a dollar a day cup of coffee and might extend your lifespan where you going to cup of coffee for a buck. I get free coffee from from here Laird Hamilton superfood machine what coffee is even more expensive than that. Yeah, it's some The Limited idea of what you should or shouldn't do to fix people as they get older my friend got his ACL torn and he's 60 and as his doctor recommended. He just rehab it and don't get it fixed. I what the fuck are you talking about?
Get it fixed man. You want to have a bum knee that just buckles on you all the time go get it fixed. Six months later would be done. Like you'll go through the rehab otherwise six months later. You still have a shitty knee. It's like your call man, but I just get it fixed bite the bullet go fix it. Right but it's doctor was like, where are come on Bruce. Come on, Bruce. Let's be honest. We're at the end of the movie not 2020 anymore. Yeah, that's that limited tank limited thinking so the frustrating to me. Yeah. I first encountered this when I was 29, actually I tried calling you at 29. It's a wrap they well they were no actually this is the problem with the other end of the Spectrum, which is I was too young to get a medicine that could help me when I get older. Oh, wow. So is cholesterol medicine the statins and my doctor said, why do you want to get on this drug? I know you've got high cholesterol, but you're only 29. Come on and I said look, why wait till I get the disease to treat it.
But you know now people use statins more but in those days it stands very controversial though. They are they apparently have a huge Health hit. Well, I haven't noticed and I have high cholesterol and I think it's worth it. But yeah if there's nothing else wrong with you you wouldn't take them but do you have arterial plaque? No, not yet. I'm perfectly clear but shouldn't isn't but isn't there some there's there's doctors that are arguing that the idea of high cholesterol that height where it's LDL HDL, which is the good cholesterol bad cholesterol this like this sort of uniform approach people with high cholesterol need to take something that Lowe's their cholesterol and doctors that I've talked to are saying. Well, not necessarily it all it you could be incredibly healthy, especially if you're not sedentary with with relatively high cholesterol, if everything balances itself out if you have the appropriate ratio of HDL to LDL, right? Do you have the appropriate Ratio or is it out of whack now, I do but when I was 29, I was off the charts.
I had I had a blood that looked more like cream and that's where one of the things apparently were dietary cholesterol does make a hit. It does have an effect on people with genetic predisposition to high cholesterol in certain ways, right? Is that correct? Right. Yeah, right but changing my diet had a big impact as well. What did you do to differ? That was different. I went more lightless. I lost weight that helped. Do you do intermittent fasting? Yeah as much as I can one of the other guys that was on this tour of Israel with me is valter Longo and he's the arguably the world's expert on this. What a great name, isn't it is an Italian guy Walter long go long go. Yeah like the coffee so here at guy calling when you got a real problem. Yeah. Well, he's he's written a book and he is the probably world's expert in human periodic fasting his
Everyone who wants to know about what the best periodic fasting protocol is there isn't one. We don't know yet. We're right on the cusp there haven't been enough studies but there are a few types I go through them in my book. So because I we won't have time to go through all of it. But there's the what is it the 18 14 hours? Yeah. It's a go if you can go skip breakfast have a late lunch. That's a good start. That's what I try to do every day. It's not always possible like when you're in Africa and they feeding you massive meal three times a day, but the that's what you want to do be hungry for part of the day, or you can go a little more extreme and skip two days. What's the benefit of being hungry great question and this is what my lab and others figured out in the Year to you know, first few years of the 21st century. We figured out that these genes that extend lifespan. These sirtuin genes are activated by being hungry in part by raising NAD levels, which we enter man.
Mimic the effect of so being hungry actually raises your lifespan in some sort of way. Right? So Clark restriction is what we used to talk about a lot. If you restrict the calories of a rat was actually discovered back in the early 20th century will make them live up to 30% longer not in an Old State but it prevents them getting old. So the rats don't get cancer heart disease and all of these other good things and that was the only thing that we knew up until about 20 years ago even 10 probably and so we used to think you had to be had to be hungry all the time and there was a still is a society called the calorie restriction society and they were hungry all the time that very small meals which is pretty tough. I tried that and gave up after a week. But this new paradigm is that you don't have to always be hungry similar to you don't always have to be on a treadmill you can do it for a short time make it intense and then you can let your body recover and go back to our normal life for a little bit and that's
Great news, that means that we can have our cake and eat it too. So to speak as long as the cake doesn't have a lot of sugar in it. Now when you are on this protocol of restricted eating plus metformin, when do you take what and when do exercise and how do you balance it out? Like what when do you know what to do what I use my body as a guide. You know now that I'm 50. I have a pretty good like, you know, you know, you know how your body feels and reacts. I'm also measuring it a ring that matches my pulse and my sleep. Is that the aura? Yeah, how do you spell that a ourour a yep? That isn't Kevin Rose a part of that companies that is that it? Yeah. Jamie says, yeah, okay from dig, you know digg.com. You don't know dig not I'm how dare you sorry? It's a good place to go find cool shit. Okay. Okay digg.com shout out to dig. Yeah, I go there every day because real interesting stories on the internet. You're always fine.
Cool weird videos and just fascinating science stories human nature human interest stories. Sounds good. I have a watch what kind of watch a using the Apple watch? Okay. How does that measure by the way? They just released Apple watch five today. Whoo-hoo-hoo. Apparently, it's better. He might want to get it was it do? What is though Apple? Watch to yeah week house it well changes songs in my headphones till the time occasionally. But yeah, what's useful with it is our pulse and activity. Hmm, and if I haven't moved in after in the day, I've got a standing desk and that's been helpful to make move around a little bit more but mainly its and also do occasional blood test to make sure that my body's optimized as best. I can personalized and using all those measures you read the data off your watch. Like how do you read it? What would application are you using? Nothing special just on my phone have a look.
Okay, so you just have a look like what your resting heart rate is how much activity how far you're walking? How many calories you're burning that kind of deal? Yeah. Yeah, pretty simple and I'm happy to say my resting heart rates really low, which means you know, things are going. Okay so far for me even though I don't do enough exercise as you rightly point out. I think my resting heart rates are 46. That's very good. It's pretty amazing for guy that Bailey does exercise. Yeah. You must have good genetics. Well, obviously do your dad's in phenomenal shape at 80 know we have terrible genetics so houses in such great shape at 80. Well, we don't know but but it could be that he's been exercising and he's also been on this Paradigm. So one of the effects in mice at least of an amen which is what we're taking is improved blood flow you get the benefits of exercise without having to exercise if you're a mouse and those mice that were running on a treadmill for 50% further because the blood flow and the lactate was reduced really, so maybe that's happening with
Incredible now, what is the difference between the effects of nmn and IV NAD which is very popular. There's people that take IV NAD and I've never done it but we've talked about doing it many times and having it brought in here and sometimes people do it and they do it very quickly when you do it. It only takes 10 minutes but it hurts like hell apparently it gives you like stomach knots and you feel terrible, right? All right, it's not done it. I haven't admitted publicly that I've done it do it, but I but I try everything once up that microphone I try everything once yeah, and so last time I was out here in La I gave it a gave it a shot so to speak. Yeah, how was it? It was fine. It was fine. Now, let's get to the science in a minute. But what I found was that was a shot in the butt with Sian 80, so why didn't they do it in a Venus? I thought that was the move they did intramuscularly. Right? Right. This doctor is
Experimenting. Oh Jesus. Yeah, it was it was a friend of a friend. So I had as I got an idea came here. Yeah come here. But here's the thing. It felt I had tingles in my legs. I felt a little different for a few minutes, maybe 10 minutes and then it went away. Yeah, but the science we don't know yet. We're still trying to figure out if that actually works or not. So instead I'm taking the molecule we've studied in my lab which is taken as a pill now. There are a lot of people that swear by the IV version of NAD and when they do it intravenously, apparently you feel phenomenal. There's quite a few people. I know my friend Kyle Kingsbury's done it several times and he's very big on the latest and the greatest of Health craze has well, I know it's being used widely especially down in Florida to treat addiction and a day interesting Ivy and I get emails all the time which is best but you know, I'm a
This time at Harvard Medical School. So I have to always be based on facts and the fact is we don't know if it works yet. Right anecdotes are anecdotes. My father's story. It's not a clinical trial, right we need to do more but what's interesting about this field is that because people have access to information through podcast like yours and through the internet. Now that papers you can go to What's called PubMed Central and fine papers people educating themselves just like scientists used to and they can go to the doctor or go to the Internet and try experiments on themselves. Now, I don't condone that. I can't I'm a researcher not a doctor, but I find it really interesting that we're in a new phase of society where people can learn more in many cases than the doctors actually. No sure in particular when it comes to nutrition because that's one of the things that I found shocking when you talk to some doctors and you talk to them about nutrition particularly supplementation, and they'll say things like well you can get everything from a good diet.
My can you really can you really like how much time did you spend School motherfucker? Like how much time did you study nutrition? This is nonsense talk. You can get everything from a good dye. What's a good diet? Tell me what a good diet is what are you getting from? That good diet. How you getting that vitamin B12 in high doses? What do you do where you getting your see where you're getting your D3? What are you getting huh? Where you getting your essential fatty acids? What's the what's a optimal level of essential fatty acids? And they don't have a fucking clue what they're talking about. You know, they don't they there's so many doctors that go through their entire medical, you know, orthopedic surgeons or what have you they go through their entire medical school with like maybe four or five hours of nutrition research, right? I have to be careful what I say, I work at the medical school, but I do I love doctors. Don't get me wrong, but we need them but we're not going to do surgery on ourselves right that said some doctors will listen to their patients and do research. Those are the great doctors that actually stay on top of things, but it's really hard right. They're already working 12 14 hours a day. So let's show Fair.
Doctors + f to work within the insurance system. I understand that there were their only problem that I have is when they say things like you get everything you need with a good dog. You remember our Three Square meals a day? Yeah bullshit to make sure you follow the food pyramid eat a lot of grain right right over that well and don't eat eggs. Don't drink milk. However - yeah, eight margarine. Yeah hilarious. What milk is a sketchy thing quite honestly because you drinking this dead liquid. It's been a modernized pasteurized and I find my body reacts very differently to raw milk than it does to milk that has been processed. Well, I wonder if anyone studied the microbiome that might be helpful to it just makes sense that it's got all the enzymes in it. It's all that's how the human being are a body any animals will send naturally process that milk. Yeah. I guess it's mostly sterile. Yeah, but yeah, I use whole milk in my day. It's surprising right because I'm trying to avoid calories but the benefits in The Taste and how I feel.
Yogurt I make myself out of whole milk that it make yogurt. Yeah. What are you wild man? Why don't you buy it? You're so short on time. What you doing? Making you making your own butter to get one them Turner's? Yeah. Well, you know, we all have our Hobbies one of my hobbies already know here's the problem. I got so hooked on this type of yogurt, which I first made for my son trying to help him. He has a weight and eating issue. I was thinking that would help him but I got addicted to the yogurt and so's everyone in my family now, so if I don't make the yogurt, they're like Dad, where's the yogurt? Oh, no kidding. So how do you do it? It's really easy there you get packets. There's three different packets. You rip them open put him in a whole milk, shake it and stick it in the the oven on defrost for 24 hours really on the in the oven. So what is defrost like where temperatures at around that's 35 Celsius whatever that is 95. So 90 95. So your
Seemed like a dutch oven or something like that when it's regular oven I meant but I mean in terms of the pan that you put oh what you mean. What's the bottle? Yes, it's just a large a mason jar. Okay and just heating it up with the probiotics inside of it. Yeah bacteria inside it. It just starts to coalesce. Yeah, and I've perfected it. The first few ones were we're not great, but now it works every time and actually the protocol on the internet said you have to boil it measure the temperature get it. All right sterilize it and I just pour it straight in shake it stick it in. It's fine. Really? Yeah so far, huh. Did you ever get it analyzed? Nope, you're a scientist. You want to send it a little cup of it to somebody or hey man, take a look at this. What are you worried about? I don't know about where your area. I'm not worried at all. I'm just curious as to whether like how potent it is, you know, there's various levels of acidophilus that you're getting from from yogurt. Yeah. I research it before I started and this is a company that makes
A yogurt that that matches a healthy microbiome the only one I'm aware of.
That's great. And you use whole milk. You don't use raw milk, right, but I don't have good access to raw milk. Would you get it let go health food store like Sprouts or you know, something like that I dry them. Yeah, I think they have it at Erawan. Maybe Whole Foods has it that's like it's really tricky because you that's not even legal in some places to have whole milk. In fact people been arrested and just locked up for having whole milk. Yes. Good luck. Google that because it's pretty Preposterous when you think about how easy it is to buy whiskey right and then think about people buying whole milk that whole milk is apparently for some people it might have to something to do with skirting FDA regulations and things along those lines. It gets very complicated for sure. And then there's are the reason for homogenisation and pasteurization is obviously Health, right? We're trying to protect people in also its Shelf
Stays on the Shelf longer but I've definitely bought it. There's a small what does it call it a small group food group raw food Club. They had they were rated in 2011. Hmm for sharing raw milk or something the latest raw milk raid an attack on food Freedom federal agents organize a sting operation against a tiny raw milk Buying Club and ignore more serious food safety concerns. Yeah, like Twinkies. I mean how hard is it? Look you can I'm sure get poop food poisoning from spoiled milk, right but isn't spoiled milk yogurt ultimately, right? Well his what I do with food if it stinks. I don't eat it good move bro. I think milk, you smell pretty quickly if it's going bad. This involved unwashed room temperature eggs, the other count unwashed room temperature eggs a storage method Rossum members prefer by
Way when we had chickens for these nasty coyotes killed all my chickens, we would store our eggs at room temperature. We put them in a bowl. We would wash the outside of the egg and put them in a bowl and they would sit on the counter and I was eating them all day long.
Nothing happened healthy as fuck Asians dumped gallons of raw milk and filled a large flat bed with the seized food including coconuts. We seize your fucking coconuts watermelons and Frozen buffalo meat. What the fuck like, what is this agents? Who are these assholes that are getting paid government money from our taxes to steal frozen frozen meat Jesus Christ Christopher Darden who helped prosecute OJ Simpson appeared at Stuart's arraignment just in time to lower his bail. All right. So Christopher Darden is out there helping people.
Whatever gross it's just a gross. I mean, I don't think you should you know, we should somehow or another find out.
Whether there's a way to test if this raw milk is fresh enough for people to eat. But if it is people live on farms have been drinking raw milk, since the beginning of time. It's normal and healthy taste better. It's way easier for you to digest like I get a little weird when I drank like straight like if I have milk and cookies, which I love I don't know what made us cookies and milk. Hmm. I might be full of shit here. Now. I'm thinking about it. The cookies might be what's messing with my my stomach. I don't think so though because you get this feeling from the milk like little book. It's probably both nothing about it's both well in France you get the the unpasteurized cheese. Yes. I'm afraid I don't Mark used to bring it back in his luggage he would smuggle back for a rock lat. You know what that is. Yeah. It's like a dish that he would make with meat and cheese. Yeah, that's good. But I don't hear the French dying in droves. They seem to be
As fuck and then I was fat, right? Yeah, their bread is better. They have bread that is not from there there. They don't have modern wheat. So the wheat that they have is not engineered to have more complex glutens and higher yield like we do so we don't buy bread in my family. My wife makes it. Oh nice. Yeah. And so we supported. Oh, yeah, let us out o the yeast is even wild she got that from Belgium friend of ours hunger. Hung some samhitas. What is it some some stuff in a tree collected the yeast brought it back to the US and really share it with us caught it like caught some yeast only put some dough wet dough up in a tree and left it there for a few days and caught this wild yeast up in the Belgian Forest were apparently it only occurs he claims but we have the best bread at home. It's crunchy. You know, you crank on it you break it open. I mean, I'm trying to avoid carbs and this is the hardest thing when you get home in the breads just come out of the oven and why
Avoiding carbs. Well, I'm trying to keep my blood glucose levels steady not Spike too much. That's pretty clear that that's not healthy and just eating a bunch of bread will be a good way to spike that one of the things that I've heard about the French and Italians in general is that they eat their bread with either butter or olive oil and that these healthy fats that you're getting along with the bread is one of the reasons why it doesn't have the same sort of Health hit and then this the complex glutens, you know, the engineered wheat that we have it when you eat pasta in Italy, it has a different effect on your body just feels different. Yeah, exactly. So there are number of people that I know maybe people, you know to who are putting glucose monitors on their arm here to see what foods they react to Radha Patrick's been doing this for a while and actually asked her. What about what's the worst Food you've seen in your body to spike.
Cause she said grapes avoid grapes really here avoid grapes.
Yeah, I wish I hadn't asked her that so now I don't know what counterintuitive right you think you're eating healthy when you have me some fruit. As I said, what was the biggest surprise? She said potatoes aren't so bad. Well, there is a thing that you could do with potatoes right when you boil them and then cool them off and then reheat them and apparently has a profound effect on the way. It impacts your blood sugar levels that it's far healthier when you there's some sort of process see if you can find out what that process was who explain that to us. Do you remember was it Rhonda probably was 99% of my nutrition knowledge. I get from Rhonda Patrick Patrick, but I believe it's something to do with the way the potato reacts to being boiled and then chilled and then reheat it again something about it. So the starches are less. Yeah ailable somehow somehow and it has a much more healthy effect on your blood glucose levels and
Doesn't Spike you in the way that just a straight-up baked potato would so be coming from Chris Kresser. Aha, even that's the other 1% My nutrition knowledge. It's probably not even probably like 6040 potatoes for gut health and weight loss. The potato hack says potato intervention of the short-term tool the check the reactivity of the got to resistant starch reset the hedonic system create metabolic flexibility resolve inflammatory conditions and provide the patient with an empowerment tool to increase the fat loss of their dietary plan. It's not meant as a standalone diet, but rather a dietary tool to decrease hunger blah blah blah blah blah blah scroll up there so we can find out what the fuck that the potato hack is explanation poor potato has been maligned. Did you did you do here's an explanation functional medicine Chris Crusher on The Joe Rogan show ha right here that scroll up magic of this plan Lisa. It's clinical effect.
Efficacy is the amount of resistant starch resistant starch as a type of starts that is indigestible to us, but feeds our microbiome on a potato is heated and then cooled a significant amount of its starch is retrograded into resistant starch. This means that the effect on blood sugar is greatly dampened the potato can be even be reheated and it will still retain its resistant starch content the nourishment to our gut biome and the subsequent metabolic benefits cannot be overstated. I've seen this be crucial in some patients who have stalled on a low carb or keto eating plan, but still have significant body fat left to lose historically resistant starch would have been present in most Roots tubers, unripe bananas plantains Etc, but is often devoid in our current diets. Hmm Chris Crasher in the house.
Yeah, well you go. So when I was in Africa you reminded me they eat a lot of blueberries. And so these colored foods are also good to eat. The Resveratrol comes on when yams dark things right? Well, yeah leafy vegetables but also our fruits that are very colored colorful. So why is that? Why is that? Well, I'm glad you asked the so we have this idea called zener mises and that's a terrible name for something that's quite simple. And that is that these molecules from plants are produced to make the plants healthier. These are stress response chemicals. And if you stress plans, they turn colored turn on a UV lamp or put a plant in the sign it'll turn reddish, you know, those are stress chemicals to survive and I believe that we've evolved to sense those chemicals in our food supply. Oh, so we're attracted to juicy red tomatoes as opposed to pale Tomatoes, but not just a driver what I think we're attracted to it because
Colorful, but what our bodies get out of it is that these chemicals go into our bloodstream and they turn on our defenses against disease to survive. Why is that good? Why did that evolve or potentially evolve? Its I think because when our food supply was stressed we need to get ready for adversity because we probably run out of food. And if you're a bird or some other dumb animal Dahmer animal or even a yeast cell how you going to know, if your food supplies going to run out? You've got it no it chemically so these chemicals are a heads up that adversity is coming. So if you eat a lot of these chemicals through say red wine, which is stress grapes and other things like that blueberries these chemicals. They're not
Probably not working mainly through antioxidant activity. They giving us this stress heads up isn't there there's that's a controversial thing. The red wine thing correct? Like whether or not read bond is the the actual compound of Resveratrol is where we're getting our benefit from because it's apparently a very small amount of Resveratrol in what red wine. Yeah sure. It's not really controversial except when people exaggerate and say that it's all Resveratrol Resveratrol is a component of dozens of healthy molecules in red wine course certain, which is good for a number of things. There's a whole bunch of polyphenols they called and so what is virtual is part of that cocktail. What is this also the fermentation process because we're talking about grapes themselves with the high sugar content actually being something we should avoid right so don't eat the grapes but wine if you don't have too much of it will have a concentrated amount of these.
Zeno hermetic molecules like Resveratrol and course certain this isn't apparent in red wine. It's really only in red wine white wine is just for chicks, right not as healthy. Not as healthy actually most right? That's a joke for my friend Bud. Yeah, you'll get in trouble my phone. No, it's just for my friend, but he always loves white wine. I'm like, that's four checks, bro. I'm joking folks just jokes. Don't get a touchy. Yeah, so you don't need to so that when we treated mice with resveratrol they were immune to the effects of a high fat diet Western diet and we've traced this down to a single genetic pathway that we work on these sirtuins. I talked about these NAD responsive Pathways really so they were immune to eating shitty food like the negative aspects of eating shitty food. Yeah that this was 2003. That's why it hit all the newspapers because it was the first molecule that was safe and could mimic the effects of fasting or caloric restriction without actually having to be hungry. Wow.
And what kind of dose are you giving these mice? It was equivalent of about 250 milligrams a day in a human. Okay. So it's 1/4 of what you recommend people take right? I don't recommend people take anything. What? Okay, what'd you take Ryan? Let's just say that. Yeah, I know recommendation. Sorry folks. Yeah. I'm taking a high dose because I've looked at human clinical data and I think that a higher dose may be required to have an even better effect on longevity. But the results are very clear when we opened up these mice maybe I shouldn't have said that when we examine those lies carefully put them to put them to sleep for scientific purposes. It was clear that they were healthier. Now there was still fat that was interesting. There was still fat so we figured the experiment didn't work but their arteries were cleaned their livers were like a healthy lean young Mouse and when we looked at their metabolism, it was like a younger Mouse. So let me ask you this then because
You take statins. If you are fairly convinced because the research of the positive benefits of Resveratrol in healthy aging and healthy metabolism and their arteries why you taking statins because you know that there are some negative effects of statins.
Right. Well if I had five lifetimes, I'd probably try that experiment. But okay, I don't want to you just don't want to risk it. Yeah, is there enough I mean have you looked through the papers the research papers on statins and a little bit there is some correlations with dementia and the brain does need cholesterol. So that might be one of the problems is your dad on statins. Yes. Really? We have a whole bunch of genes that predispose 23 meet said basically give up now. Wow, it's pretty horrible. So yeah if I make it to 80 mm doing pretty well.
Interesting
because Bourdain when he was alive, he had made a decision to take statins versus change his diet. This is before you got into Jutsu when he was traveling the world and eating the finest foods and drinking wine to excess every night and join the shit out of it, you know, we had a conversation about it's like I would rather eat well said I'd rather eat well and take these drugs because I know the side effects. I know they're dangerous. So then we have a conversation maybe two years later. He gets really into Jiu-Jitsu his wife at the time was in to Jujitsu and you know, she had convinced him to try it and he went and tried it and immediately got hooked and he has or he had a addictive background, you know, first was heroin and you know some other unfortunate substances and then cigarettes for a while. He quit that and then Jiu-Jitsu became his new addiction and he
Ripped I mean he really at I think he started training at 58 or 59 started and then by the time he was 62, you know, like full six-pack was crazy to see like I'm like look at you man. This is nuts. Like this is an image of him walking down the street and I mean he has no shirt on and he's fucking shredded got off all the statins got off. Everything has changed his whole his issue with cholesterol. Yeah good on him. Just through daily exercise. Yeah, I should try good. Yeah a little bit of shame that I haven't been able to get off the statins, but they just scare me man. I just read too many things. Well, you know, I could have gone off them when I was on a really lean diet. I tried this Okinawa diet from Okinawa Okinawa. Yeah, so just fish mostly and and and tofu hmm. Yeah, how'd that go? I was great. But then I had kids. Oh, you can't feed tofu to kids if we do right. You can have separate food just for
I'm not going to snow although I understand. Yeah, but your yeah, that's the thing is like you are so limited by time, you know, you're so you have such an involved research schedule and life schedule and travel schedule. I'm a pretty average guy. I'm not militant about what I eat. I try my best every day to do what I can but the Statin thing I just haven't had the chance to do it, but it was virtual. I don't think it's sufficient to keep these cholesterol levels down. So combination so far when you first got on the how long you been on statins since 29. Oh wow. So you really have been on them for 21 years. Not only that super-high dose. So it's 80 milligrams. What's a normal dose? 10? Whoo, that's crazy. Yeah, my doctor wanted the best at Harvard. I looked at my genetics and said you're fucked. Yeah, I got all the wrong --jeans these tiny little lipoprotein particles the ones that oxidized so the fact that my arteries apparently cleaners is good. Good news for me. Well, that's good.
News, like I said look good. I don't think so. Obviously, there's a lot of biodiversity when it comes to human beings and some things that are bad for others.
Good for some well, I'm not losing my mind yet still pretty functional when it starts slipping away. What you going to do? Ask your wife or your friends or what do you do? Yeah. What am I gonna do? What if your dad's want to tell you? Yeah, that could happen Mark right? He's 85. Yeah. My dad was changing my diapers. Yeah, David you asked me the same question three times in a row the way it's going that could definitely happen. Well, do you get a lot of sleep? I do now now that I'm monitoring it. Yeah. What's a lot of sleep for you between six and seven hours? Oh, that's good. Dr. Matthew Walker was a guy that I had on my podcast who study sleep and he was fascinating and it changed my entire opinion about what's necessary. There's a direct correlation between limited amounts of sleep and Alzheimer's direct correlation. He's like, it's one of the most established links that you can see between a disease and a Cause
Yes quoting it's an association. You know, I always wonder you know, I'm a scientist always have to be skeptical sure as to whether if you're predisposed Alzheimer's you have trouble sleeping and you start taking Ambien. Now people say well and being an Alzheimer's are correlated. Well, yeah, maybe it's the other way around. Yeah. Yeah me and scare the shit out of me. You don't take that do tiny bits? Oh that stuff's not because people take it and they say things they don't know what they're saying. Right? Well the recommended dose at least it used to be for men is 10 milligrams, which is massive. I nibble on I take maybe a milligram just to nod off if I'm desperate which at like hmm But yeah, I picked doctors many. I know say the 10 milligrams is probably too high but check with your doctor. Yeah. Well Matthew Walker says stay the fuck away from that stuff period he said you're not getting real sleep. Anyway, you're not going in through full sleep cycles. You just drugging your brain into a state of unconsciousness. Probably 10 milligrams that make sense for me cuz I'm
During it. I know that I'm getting good deep sleep. Have you tried other like melatonin things along those lines - oh so not effective not as much sometimes melatonin with milligram of Ambien is necessary. But what a big change for me has been just don't stay up watching TV get the screens off with ya classes. They really help. Yeah, the screens are watching those goddamn screens before you go to bed. I love doing it though. I love watching TV show before I go to sleep. It's probably the worst time to do it though, right? Yeah it is it really I mean you can watch the shows just put the yellow glasses on you know, the blue light emitting. Yeah blocking glasses one of my sponsors movement watches. They have the blue light-emitting glasses need to get those, uh, blocking or omitting blocking blue like blocking. Yeah.
Yeah, not admitting how can a glass of it, you know blocking blue light-emitting sickness. Yeah. Well, you can have blue light-emitting glasses to that'll be good really well for the middle of winter. Oh if you get depressed, yeah. Well were you live there is no real middle of winter here buddy. We're used to you used to live to yeah, not too far from where I worked. Yeah. It's pretty tragic middle of winter. I want to kill myself. So just that seasonal affective disorder. That's a sure. Yeah. Yeah. Yeah because I'm working indoors. I don't see Sun for months. Well that gray sky when it's every day is gray over and over again. You see no real sky for so long. It's so weird it. Yeah, I Miss Australia for that reason. Mmm, I get reinvigorated if I come out to LA and his blue sky, you really feel different. Oh for sure. There's a reason why the fucking billion people out here. But what is your strategy for mitigating the impact of seasonal affective
disorder?
What I do I try to go outdoors and get some some sun in my eyes when I can take vitamin D offshore. Lots of a different eye seems to have helped make a difference. Yeah, so your vitamin D that it's questionable whether it's as healthy as people thought it was that said I think it worse doesn't hurt you. Some people do Sun lamps for that reason, they'll go into a tanning booth for the reason right? They will actually found this season. I went to the sauna in the cold shock bath and that really helped a lot. I don't know if it's related, but I needed to shock my body in the middle of winter if you just sitting by a fire and barely moving around I just felt like it was a sack of shit. And so a lot of people get fat in the winter to Let's another thing they just they get indoors because it sucks outside. They never want to do anything and then you dealing you're dealing with the depression of being a little bit heavier to Offshore and then you drinking violent violent kind of stuff, but it's all
Shock your body get your body out of complacency and our lifestyle everything we do everything we buy everything on TV that's being advertised to make your life better is shortening your lifespan by making it easier for our bodies to exist. You don't want that. You got to stress it. Yeah, what other things do you think that people should be doing on a daily basis that most folks aren't
well we covered a lot.
So there's the the be hungry get the exercise. There's all sorts of exercises which are good, but the main ones are stretching and running and lifting. Okay cold and hot we've talked about
And then there's the supplements that mimic the benefits of those plus probably more things. That's my that's my regimen. There's some other little tidbits that I put in my book, which it's a laundry list of things that I found work for me, but those are the main things we've covered. This is sounds probably pretty boring but I'll say it again wear sunscreen for two reasons. I mean, you look better anyway, not the probably young people care, but we'll make a difference by the time you're our age but also because DNA damage does age you we think that it's breaking the chromosomes and that's the major driver of Aging that sun will do that x-rays will do that maybe even airport scanners. I certainly am not a real devotee of getting scanned. I thought they were radio waves are there the millimeter and they don't penetrate very deeply so they're probably not too bad, but I've looked into it's about the same radiation as you get on the flight and given that I'm doing
Million miles a year. I don't want to double the amount of exposure. So when you go through that radio scanner, then the more modern TSA scanners, they give you the same amount of radiation as a flight because a flight gives you the same amount of reishi radiation as multiple x-rays, right? Is it that other thing is that bad? I believe it. Okay. Well, let's look at this. Let's find out how much radiation do you get on a five hour flight? And is it comparable to multiple x-rays because I believe that's what I read. Well the X-rays I can say definitively based on my research. Would Age you agent issues. What's it doing to well, it's breaking your chromosome and causing that clock that I was talking about earlier that biological clock to accelerate. Is there something you can do to mitigate that if you know, you have to get an x-ray should you do something right afterwards potentially potentially you could take in a man which we've shown in mail in mice protect them against the effects of radiation and that's one of
Things we've talked in s about for getting to Mars and back safely. So when I'm on a flight, I takes a man to man in the expectation that it's going to boost my body's ability to prevent those changes to the clock now. Is there a commercially available and a man that you would suggest if someone wants to purchase it somewhere well, so I don't divulge company names and there's two reasons for that one is I've been tested them so I actually literally don't know but the other is that I want to stay above The Fray and Anderson not get involved. But it but there are if people want to go Google and go look online. They can find commercially available nmn, right? So yet again, I've got number of pages in the book on that. So it's all laid out but open summary this part right here ladies and
gentlemen
lifespan why we age and while we don't have to
Thank you, sir. That's my MPR voice. Yeah, you can donate if you enjoy programming like this putting me to sleep. That's what I do man. Something happened with people. They thought to be intelligent. You have to talk like you're ready to put people to sleep. It's time to get sleepy anyway, so the enemy man, so there are people who selling it on the internet and just just to get the facts straight. I don't sell anything. I understand. My name's all over the internet. If you see my name with a company, it's BS, uh-huh, beautiful. That's good. Anyway, so the nmn there are companies that sell it's more expensive than another molecule that's related called NR or nicotinamide rye beside which is also what the body can use to Boost energy levels and that's a little bit cheaper and they both been shown in animals to be to boost the sort of to ins and help those animals be healthier in old age and reverse some aspects of Aging like endurance loss of endurance that kind of thing.
Protect protect the I protect hearing as well so that we don't know if it works in humans that let's be honest. We don't know if these things work, but let's also be honest. We know what's gonna happen if we don't do anything and that's not pretty either. Do you have any high hopes for things like crisper things where there's going to be genetic alterations and they are starting to do some experience. You have a big smile on your face right now. So I'll let you talk tell me what's up. Well, so I'm a geneticist and I'm just down the hall from George Church who's in my department at Harvard and I'm a big believer in crisper in the sense that it will revolutionize medicine now right now explain it to people don't know which means so crispr is an acronym for basically a system that is from bacteria that they use to kill and destroy the DNA of invading organisms like a virus, but we can now use that system.
Cut and change our own genomes. It's basically a DNA cutting enzyme that doesn't cut randomly. You can give it a bar code in the form of what's called RNA molecule that tells where that ends I will cut in the genome. Let's say you Joe Rogan have a terrible Gene that's causing heart disease. We take this crispr system. We say here's where you need to go to cut we can tell the enzyme to go and cut it put it into your cells. It'll go cut it and destroy that enzyme and delete it and you can also use it to cut the gentleman and insert New pieces so you can both subtract and add DNA at will now not just randomly, but what's important is you can tell it where to go and that's the big breakthrough.
And they're doing some experiments on human beings. I know there was something that they were doing beliefs somewhere in Asia. If I remember correctly, I believe it was China where they had done some manipulation to people to help prevent AIDS and in the process of doing so they may have boosted intelligence or the potential for intelligence, which was so convoluted that my puny little brain can understand the study. I was chose to go over the same paragraph like four or five times. Just try to figure out what the fuck they were saying. Am I making any sense? Yeah you are you are and that was a study that I don't believe it's been published but it's been reported right that he is his name his last name. Is he he took embryos and engineered them to delete ccr5 Gene, which is required for HIV to infect cells. Now. That was we can we most of us scientists think that that was
Reckless for the fact that first of all HIV isn't a huge risk in China to one in a thousand chance of getting HIV. There are plenty of other things other things. They that you could do that could be more helpful. Let's say why not mutate what's called PS canine to prevent heart disease which would probably have 50 percent to kill the boys a boy. So anyway, it wasn't the most risk benefit ratio modification that that's one thing but the other is we don't know what happens when you cut jeans in embryos. Does it have changes to the DNA clock? Did it accelerate their aging did it mess with other genes did it cut in other places and scrub those doing we don't know that yet. And so that's why the scientific Community had a negative reaction to it. But what's interesting is that the scientific community and the Press has pretty much gone quiet on this.
Imagine if this happened during the bush era. We have protesters all over the place it be outlawed and that hasn't happened. I think it's because we live in a world with a 24-hour news cycle though, but isn't that also because it's being if it wasn't during the bush world, I mean where the protesters really take place if it was done here the thing about things that are done in China or overseas like huh? It's like it's so far away like well, it's keep an eye on them. Yeah, that's true. There is the fear that some countries going to engineer and army of supervillains. I mean the we have the technology to do that right now. Yeah, we believe we understand how to slow aging there are genes that predispose you to to long life we could make
Offspring a family that would potentially live a lot longer but it's just something that can only be manipulated in embryos or in fetuses. No now we can do it in adults. Actually those does it there are drugs that are in development to actually correct genetic diseases such as vision loss really do my eyes are gone. I can barely read like print on a laptop. I I need glasses to read my laptop. All right, so we just put up a study online on a site called bio archive anyone can go there and see it. Just Google my name and bio archive B IO R XY V reason that's interesting. Is that what we're showing is in mice at least we can reverse the age of the retina and restore the vision of old mice.
What do I have to do?
Well, I think you have to blow me a few more days. Come on, man. Well lose your job. Let you got to let me Crack those kind of jokes. Sorry David. I was joking. I started it folks. Yeah, it's not his fault. What so what would someone I mean is this going to be available to the general public any time in our lifetime? I tried my best we're hoping to do clinical trials starting in two years from now, really and what would you do in those clinical trials? Also, we'd reprogram the I to be young again. So we now know that there's a set of genes called reprogramming factors also known as yamanaka factors that are from named after this Japanese fellow who won the Nobel Prize in 2012. These factors are used all over the world even probably in high schools to reprogram skin cells are the cells to be what we call pluripotent stem cells. These are cells that can be used to make new organs or you blood cells but what people hadn't tried until recently was can you do this in a living animal?
Or he just going to mess it up and what we found out is that if you do it the wrong way you mess up the animal and it'll die. But what we've shown for the first time in this paper is you can do it in a safe way and not only that reverse the clock make the cells young and restore how they work and get back vision. And what's the methodology right good question so that the current method is using a virus that's on the market. These are called aavs a dental Associated virus has you put them in the eye they're already patients getting this in the on the market. Really? Yes Park Therapeutics is an example of a company that is curing genetic diseases in the eye with viruses or in a new world. Most people don't know about it. Wow. So what is the company again? Jamie? We have this spark genetic engineering but there are changes already got it. Look at that bam motherfucker Jimmy Vernon the house. So these folks are already doing this to people. So is this for people that are sort of desperate and they'll try
Something experimental right? Well the desperate in the sense that there's no other choice. No other cure. I mean we're now curing genetic diseases. Someone was just treated and cured of sickle cell anemia that's phenomenal and that you know, I learned that that comes from malaria, right that was the idea that people were the resistance to malaria. It was such that trait from people that evolved in the area where they would get malaria was. Also what led to people getting sickle-cell, correct? Correct so that I learned that from Tiffany haddish by the way amazing Tiffany shout-out Tiffany that lux turn a stuff.
Is this something that someone like me could take right now?
No, not easily. Your doctor would need to prescribe it and so if you did describe it, I could literally get Vision back. Well, this is not the same technology that I'm talking about it from my last has inherited retinal diseases our commitment to our IR DS. This is Gene replacement. What not reprogramming the body to be young but it's the same virus that we'd use to correct. So they're using this for certain retinal diseases or they're correcting it. Now. How is this bacteria fixing your vision? Well, the virus is adjust my age to get the genes into the cells that's all and that these are benign viruses. They don't hurt you, but there are carrier and it maybe eventually we'll have other ways to do this. But right now the virus is the best way and in the mice to restore the vision we have this 3 Gene combination of these yamanaka reprogramming genes. We put them into the eye and then we turn them on with a drug. In fact the same drug that I took when I was in Africa.
Cold doxycycline is the same drug. We can feed to the mice turns on the reprogramming genes for a few weeks restores their Vision back to a young Mouse and then we just take away the doxycycline an antibiotic and the mice have the vision back and how long does it take for it starts deteriorating and we don't know yet but along that it's permanent because the age of the cells is gone back. Those are young guys again, so you might have a whole full cycle from like 20 or 10 to 40 years old again, that's the future that you'll get a delivery of this virus. You'll take the antibiotic for a few weeks be fully rejuvenated and the doctor says come back in a couple of decades will fix you again. I will give you some antibiotic and a couple of decades but then it gets really weird. If you have a if you engineer your children to have this system if that ever happens, let's imagine it could we could do this right now with technology and you have people engineered to be able to be reversed in their age or let's say the have an accident and there.
Take note of gets damaged or they lose their hearing from a bomb or something that spinal injury give him a dose of IV of antibiotics and they become just like an embryo that can rejuvenate they can regrow their optic nerve regrow their spine fixed back back like new the the vision thing. Do you think that we're going to see that in our lifetimes mean? Is this something that you're going to see that's going to be available to the general public while so I've got an entrepreneur as we discussed before and also one of the companies that I've started is exactly that raised money to be able to make this virus. We're making it now takes a few million bucks and we'll hopefully with the fda's approval injected into people's eyes. Now first, it won't just be guys like you first of all we have to go into an area where it's FDA approval which is a disease like glaucoma, which is pressure in the eye or macular degeneration. That's our first goal. But then if it's safe, why not do all those wow.
That's incredible. What about people with injuries Yeah. Well, yeah, you could theoretically put it into the spinal cord or give it give an IV but people with eye injuries. Oh for sure. So one of the things we also did in this paper that we put online is we pinched the optic nerve and what normally happens is it just a grades. I mean nerves don't grow back right unless you're a baby mouse or a baby human, but we made those cells. So young that the optic nerve grew back to the brain. Wow. First time that's been able time. Noah guy have it from fighting. He's got a detached retina detached so bad that his vision in his right eyes extremely poor. Shout out to Michael Bisping. Do you think that that's something that inside of his lifetime they could see something use of this technology that could regenerate his I well I get a lot of emails so I'm not really trying to over promise anything. What I think is possible is that initially it'll be used for disease or chronic disease then it'll be used for in
Like like that, but fresh injuries, I think it's probably likely to work better if it's fresh. Hmm. I don't know where this technology is going. I can imagine a lot we can all imagine that you could get Vision back and people walking again, but that's where this technology is going. We only so I described the discovery in the book as actually what happened while I was writing the book is Will making these discoveries and they were remarkable and so I wrote them down in the book as we went along so people can see how it feels to be a scientist to make these discoveries, but it's only been a year or less that we've known about this. So imagine 50 years from now what we can do even 10 it's going to be a remarkable future. It's very exciting. Now what kind of a timeline are you anticipating for bringing this to you know, people with injuries well injuries already. We have a study plan for spinal injury in mice and that will probably know the results in not less than a year and then we could as fast as the FDA allows us go into
Clinical trial now is the same scenario applicable for people Spiner in spinal injuries as Vision, like people that have a more recent spinal injury, where be more likely candidates than people that have had older spinal injury, I think so that would just be my guest that it's easier to fix a recent recently damaged system anything in the body, that's fresh but I wouldn't rule out anything when we when we first discovered this the experiment was to have a fresh injury the pinching of the optic nerve, but then I said to my student why don't you just try old mice and he said, come on Old mice you kidding me. How's that going to work? Just try it? Just try it. I saw he did it and in collaboration with another Lab at Harvard, so they're the experts and so Bruce Cassandra's is name. So Bruce called me professor at Harvard is 10:30 at night. It just got off a plane. He said David you won't believe it. I didn't believe it. I just looked at the data it freaking worked. Wow old mice are seeing again. He said I want to go down to the FDA and tell them about it because right now I diseases typically
All he can do is slow them down and here's actually a reversal of lost function knows this apply to injuries as well. Do you believe old injuries or just old macular degeneration? We'd haven't tried all the injuries now Michael we've done glaucoma, which is an old injury. Okay. So theoretically what we could do is at least with the existing nodes if they're still attached we should be able to rejuvenate those and make them work better because he has some vision is I so yeah, so that's possible that that makes more sense but very little very limited in one eye. Yeah. Well, we'll have to see interesting because you didn't think I was going to work on the old mice I did but no one else did WOW crazy. Well, we're literally reversing not just the effects of Aging but aging itself. So if I gave you those retinas are a little retinas here you go Joe and you're a scientist. You could look at that retina and analyze it molecular Lee measure its clock and you'd say those are young guys and you would know the difference now, do you feel like this?
Kind of technology is also going to be applied to see people skin because you know, one of the things that for women it's devastating when they develop wrinkles, you know, they fucking hate it men get a few wrinkles the kind of look distinguished, you know, but man when women get wrinkles they freaked the fuck out they don't like it. Yeah, we're going to try it on on aging on the skin though, you know when I talk about making people walk again potentially. Mmm. It's probably a higher priority for sure, but I think it's feasible. So there's a lab at the Salk Institute Juan Carlos Belmonte who may win the Nobel Prize for his work on this in 2016 and a couple of years since he's been showing that it doesn't just rejuvenate old mice. It actually is also rejuvenating the skin if he puts it on a wound that's in an old mouse that Mouse will heal it will heal better. Now that doesn't prove wrinkles, but it does prove the skin can be rejuvenated as well. So the could be possibly some sort of a treatment to skin.
Maybe a re-injuring like a view there's this thing that they do I think it's called a vampire facial of you ever heard of that. They take platelet-rich plasma and then they micro needle your entire face and then they somehow another apply this platelet-rich plasma to the areas that have been micro needles and it has some sort of an effect and increasing collagen and elasticity of the skin and tightening of the skin. We've heard of this I've heard it for. Hey Lois, I didn't realize people get over their face or hair loss as well. They're doing it sounds painful. So to me, it makes sense that it might work the plate the PRP is as it's called is full of factors that we know some of these are rejuvenating in mice, you know, this the system where you can hook up an old mouse and a young Mouse circulation. Yes, and you get Rejuvenation. There are factors that many of which we haven't discovered or identified that exist that you can rejuvenate and I would bet that they're working.
Most likely through this reversal of the clock. And so one of the things we're doing in my lab is taking what are called exosomes which exist in these preparations and seeing if they reverse the clock I've had axes. Ohms shot into injuries for stem-cell Watchers. Yes. Yes did work that make sense? Yeah. I had a full-length rotator cuff tear that's completely gone. Yeah, so maybe what's going on is you free program you body there? Yes. Well, there's it's a weird thing the exosomes and stem cells and there's a new product called Wharton's jelly. That's also very effective and potent because there's not a lot of papers on these things. It's all you know, the research on it is some of it's a little shaky but the efficacy at least anecdotal efficacy is pretty substantial and I'm one of those pieces of anecdotal evidence. I've had a bunch of shots. I just whenever I get injured like shoot it up. Yeah. Well you listen is may not know about exercise.
Exorcisms are little compartments that are pinched off from cells and put into the body and communicate between cells across so your liver can communicate with your brain. Yeah, for exams and within these little car goes there are things that we just discovering little proteins RNA and they're full of goodies and drug companies are being built on these X's. Ohms. Yes. I'm glad you brought up the study of the old mice and the young mice where they put the blood in the old mice and then the old my started behaving like young mice and the blood of the old mice the young mice and the young my started behaving like they were tired because there's a company in Northern California that's supposedly doing this with humans where they're injecting people with the blood of old people or young people rather some sort of transfusion. Not anymore. Not anymore. They had a business. Well, my understanding is the FDA sent. My letter said stop it. That's it. Just a little bit salt eggs. Oh, yeah. You don't want to go to the next down the street and
Your name? Oh, I got another letter live down the street change my name I think that's risky. Is it check to see if their companies under alcaraz? I do not remember the name of it. But I know I remember they were erroneously link to Peter teal and then Peter denied that he's ever used that you know, the billionaire founder of PayPal who I've met some wonderful man. They erroneously someone just some story linked the said that he's at getting it. He's like actually shut the fuck up. No, I'm not don't say that. I've never done it not doing it. So it was one of those things where there was a lot of Legend to it because of these my studies. He's my studies get people super excited about the idea that all you have to do is get young people's blood. So you get a bunch of young people with healthy disease-free drug-free donating their plasma doing their blood for x amount of dollars a quart right? You have a blood boy. Okay, so yeah blood boy. Hey, man when I was young I needed some cash.
I was healthy. Come on regenerate that shit. Yeah, you know it quarter blood I get it back in a couple hours. I think it might work. It's just that we don't know the consequences and the fda's job is to protect us. Yeah, just like they're protecting us from raw milk bunch of pussies just recently shut down about a month ago. I missed the boat could have been in there man. But if you did that that's something you'd have to do on a routine basis, right? It's not like something you do one one shot probably give you a little boost for a short amount of time. Yeah. Well, that's what's different about this reprogramming. You do it. Once you come back easily. Yeah, the eyeball thing is very enticing to me because it's so weird watching my eyes deteriorate like slowly but surely I'm watching it happen. It's really it sucks. And it's a sign you get an older man. Yeah age-related macular degeneration to seems pretty standard except my friend. Cam Haynes that motherfucker. He's 52 years old. He could see Lacey like 2018 Vision at 52. It's crazy. See anything. I dropped my
Phone on the ground is like I you got a crack. He saw it from like I'm where where's the crack? Like? I'm trying to look at in lisak right there and I put reading glasses on like son of a bitch like how the fuck did you see that? He saw it from like where you are like looking at the phone like that is crazy. Well said so let's keep in touch we will and yes, if we get this on the market then uh-huh. Yeah. Yes turns out he has started up again as recent pretty recently but it's not being sold as Youngblood for plasma is just plasma. So just give it a shot bro. Just no promises. We think want to go in there with me right after we do the cryotherapy beeping. Let's get some blood some young blood try doctors behind failed anti-aging blood clinic tries. Again. We tried to ask him some questions, but he was very evasive good for you sir. Duck and move do the old Muhammad Ali rope-a-dope.
Be like Pernell Whitaker, sir. Yeah, I hope he stays evasive. I mean, it's also like maybe it's nonsense. Maybe it's not would you like to do studies on people that are doing that and find out I mean, well what they should do is measure the clock now that we have is right. Yes, that would be interesting but based on what we know about how it works with mice you think it's likely that there is some effect it's possible. It's possible. I like how you very cautious your real Professor. I like that's right. You're the real deal. I'd like to keep my job dog. You should stop making those blowjob jokes
are
funny that that is actually controversial two friends catches joke. Is there anything else that you think is promising that is on the horizon or that's being discussed or theoretical?
Point yeah, there's something that is really interesting and that's called Santa latex Santo Linux. Yeah. So Center latex are drugs that kill off senescent cells. So what a senescent cells these are often called Zombie cells and what I think is to World War Z. Yes, a lot of zombies this podcast so senescent cells we've known for decades exist in the body, but what was not clear was whether they cause aging now, it's pretty clear from animal studies at least is that we get lots of these accumulating and that they do cause aging and one of the best experiments that we've done our from Mayo Clinic was to genetically delete the senescent cells that accumulated in an old mouse and it became young again, or at least it delayed its aging by Fair bit now senescent cells are pretty rare. There's not a lot of them, but they cause Havoc because they don't just sit there in the body, but they send out these inflammatory markers and they cause cancer we think so you want to get rid of these?
Um, just I want to mention that in the biological clock when I was saying that the clock is part of the aging process. What we think is that as we get older that and it's detailed a lot more in my book. So if people read it, they'll understand a lot more what I'm saying, but this this clock is messing up the cells ability to be what it used to be what I mean by that. Let's take your eye in your retina. Your nerves are getting older but your nerves we think I losing the ability to read the nerve jeans. So they're forgetting that their nerves. So now they're starting to behave actually more like a skin cell and having a skin cell in your eyes not going to really work very well so that we call that epigenetic noise epigenetic aging reprogramming resets that so why is that interesting? We think that the ultimate problem for the cell when it loses its total Identity or gets a long way towards that is it shuts itself down because it says fuck I don't even know what I am anymore.
Or not enough cylinder skin Solomon a liver cell sin s siness means stop dividing just sit there and tell the body come kill me. Okay. So now they're putting out these panic factors. There's a problem you get inflammation the problem. Is that as we get older the body's not very good at clearing out these cells they sit there and they wreak havoc yet inflammation. We think you get aging. So getting back to Center latex. These drugs are designed to be a pill or an injection into your joint to kill off these zombie cells the senescent cells and theoretically rejuvenate the tissue and reverse that aspect of aging and that's another treatment like reprogramming that could be a One-Shot delivery and take you back a decade. Wow, and how far away are we from seeing those much closer? Actually, there's a few companies. There's one called Unity. There's one that I'm involved with in full disclosure called synthetic Therapeutics in Europe and are there in
Least Unity is in clinical trials right now for osteoarthritis really now. What about the company in Europe preclinical still Mouse? Wow. So we looking at like a decade from the general public or well the unity they hope not usually when you're in a phase two study, which they're in it's a few years away if it works. Wow amazing stuff. It's such a cool time to see all this medical Innovation technological and scientific innovation. Well, my head's spinning yes crisper and then the reprogramming which is new stuff. This is stuff that we dreamed of yeah, but thousands of years and you know, I don't think it's a dead end and it may not be as you know, we're not going to go back to being 20 anytime soon that said, I think we've we've had a major breakthrough the equivalent. I like to use is we figured out how to fly where the Wright brothers right sisters. We've got got include
This is now my daughter will tell right non-binary people. Yeah, so my daughter change your name, by the way, so what to aleksandr? She was Madeline. She didn't think that was appropriate why she's a tough chick. She's a day and so I'm not allowed to call her. She I don't think she doesn't want to be identified as one of the other interesting. She's 16. She changed it at 11. Whoa. She's a tough girl, you know in my family we tend to be Rebels and unfortunately it passed along I'm getting everything back fortunately or unfortunately. Well, I guess I'll be proud of her but raising over the last few years have been pretty annoying at home can't say anything without the pr police. She's that's hilarious. So PC police are PR. Did I say PR? I'm a PC. Yeah, that's interesting.
What was I saying about my daughter all about the name change? Yes, I was it took about a name change. I don't know you tell me Jamie's remember man. We got a million people screaming a toaster. Yeah. Well you were talking about so many exciting things on the horizon. Yeah true. Yeah, and so that it's just head spinning and so much is happening in our lifetime that I thought was just imaginary or for the future. Now the question is are we going to reap all the benefits of this or we're going to be the last generation to lead a normal human lifespan and I don't think we are I think that we already have things we can do in our daily lives just in lifestyle and in molecules, you can take that give us a very good chance of living beyond what's naturally possible. This is amazing and such. It's so exciting. And the last time you hear was about a year somewhere around that range. Yeah, I mean and think about how many new things you have to discuss Now versus then it's really interesting man, and I'm so happy that people like you
They're out there doing this. It just it's so it's just so exciting and it's so it makes me very happy to know you're out there. Thanks, sir. So thank you and your book people can find out all this stuff in detail much more detail than get the two and a half hour conversation lifespan why we age and why we don't have to David a Sinclair PhD. Thank you brother. Always good time. We'll do it again. Next year deal. Yes.
Bye everybody.
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