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In particular, there's a signature pattern of depression whereby cortisol, the stress hormone that normally is released in a healthy way only in the early part of the day, is shifted to late in the day. In fact, a 9 PM peak in cortisol is one of the physiological signatures of depressive-like
states.
Andrew Huberman
Major Depression Often Causes Sleep, Appetite, & Hormonal Disruptions
Understanding & Conquering Depression | Episode 34
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