The most extensively studied NAD booster is nicotinamide riboside. Several animal studies have shown that when nicotinamide riboside is orally administered at high doses, it can counteract an obesogenic diet by improving insulin sensitivity; it can improve endurance and strength. Another animal study showed, at high doses, nicotinamide riboside could reverse mitochondrial damage, it could increase mitochondrial biogenesis, and reverse muscular atrophy in animals that had a severe muscle-wasting disease.